ida(缺铁性贫血)_ppt课件

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1、IronDeficiencyAnemia(IDA)Dr.LiuChonghaiIron-deficiencyanemiaaffectedabout1.48billionpeoplein2015.Alackofdietaryironisestimatedtocauseapproximatelyhalfofallanemiacasesglobally.Womenandyoungchildrenaremostcommonlyaffected.In2015anemiaduetoirondeficiencyresultedinabout54,000deaths–downfrom213,

2、000deathsin1990.Disability-adjustedlifeyearforiron-deficiencyanemiaper100,000inhabitantsin2004.MetabolismofIronA.IrondistributioninthebodyC.Physiologicalrequirementofiron:1mg～1.5mg/kg/d(<15yr)Premature2mg/kg/dIndexofironnutritionTIBCandironsaturationinIDAEtiologyofirondeficiency1.Insufficie

3、ntironstore:premature,severematernalirondeficiency,intra-uterustransfusionetc.2.Insufficientintake:foodwithinsufficientiron,e.g.fedwithmilk,flourorriceflouronlyetc.3.Absorptiveproblems:chronicdiarrhea,steatorrhea4.Growthdemand:younginfants,prematurebaby,adolescentchildren,girlsaftermenarche

4、etc.5.Bloodloss:chronicgastrointestinalbleedingcausedbypepticulcer,hookworm,multiplepolyps,angioma,diverticuloritisorinflammativeenteropathy,oracutebloodlosswithinjuryorepitaxisetc.3stagesIrondepletion,ID:Irondeficienterythropoiesis,IDEIrondeficiencyanemia,IDAImpactonbodyhealthbyID1.Hematop

5、oieticsystem:gradualanemiaStagesFerritinSerumiron,SIHbIDLowNNIDELLNIDALLLImpactonbodyhealthbyID(continued)2.GIsystem:absorptivedisorders;3.Circulativesystem:cardiaccontractivitydecrease,heartenlargement,murmurandheartfailure;4.Neuroschycologicalsystem:insomnia,attentionabsent(aprosexia),apa

6、thy;5.Immunesystem:compromisedimmunity,susceptibletoinfection;6.Skinandhairsystem:drynessofskin,sparseandbrittlehairs,lossofpolish,fragilenails,koilonychia;ClinicalManifestationAge:6months~3yrsGeneral:anemicpale,positionalhypotension;GIsystem:diarrhea,dyspepsia,nausea,vomitingHematopoieticS

7、ystem:hepatosplenomegaly(extramedullaryhematopoiesis)Circulatorysystem:tachycardia,murmursandheartenlargement;Immunesystem:infection;Neuropsycologicalsystem:pica,apathy;Labtests--Bloodsmear:MicrocyticandhypochromicRBCBMsmear：Cellularity:hypercellularity;