调脂治疗对高脂血症合并糖耐量异常临床疗效观察

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1、调脂治疗对高脂血症合并糖耐量异常临床疗效观察【摘要】目的观察不同调脂治疗方案对高脂血症合并糖耐量异常的疗效及安全性.方法将157例高脂血症合并糖耐量异常的患者随机分为三组，即血脂康组，辛伐他汀组和生活方式干预组（对照组），治疗6个月后观察疗效。结果血脂康组及辛伐他汀组治疗6个月后TC、TG、LDL-C水平与治疗前对比有显著性降低，HDL-C显著升高（P0.05）。血脂康组FPG、2hPG及HbAIc与治疗前相比差异有统计学意义（P0.05）。结论血脂康更适合高脂血症合并糖耐量异常患者，能有效降低高脂血症及改善糖耐量异常，且安全性良好，值得在临床推广。【关键词】调脂治疗高脂血症糖耐量异常

2、分类号：R589.21文献标识码：A文章编号：1005-0515（2011）7-054-03Clinicalobservationonlipid-regulatingtreatmentforpatientswithhyperlipemiaandimpairedglucosetoleranceXIEYuanlinglZHOUZhiheng2HUANGYanpingl(1.Generalpracticedepartment,thesecondpeople,shospitalofYuexieDistrict,Guangzhou510180,China.2.Schoolofpublicheal

3、thandgeneralpractice,Guangzhoumedicalcollege.Guangzhou510000China.)[Abstract]ObjectiveThestudywasconductedtoinvestigatetheclinicalefficacyandsafetyofdifferentwaysoflipid-modulatingtreatmentforpatientswithhyperlipemiaandimpairedglucosetolerance.Method157casesofpatientswithhyperlipemiaandimpairedg

4、lucosetolerancewererandomlyallocatedtoxuezhikanggroup，simvastatingroupandlifestyleinterventiongrouprespectively.thetherapeuticresultsweretested6monthsaftertreatment.ResultsAfter6monthstreatment,thelipidprofilewasevidentlyimprovedinxuezhikanggroupandsimvastatingroup.leveloftotalcholesterol(TC),tr

5、iglyceridemia(TG),low-densitylipoproteincholesterol(LDL-C)weresignificantlyreducedandhigh-densitylipoproteincholesterol(HDL-C)increasedsignificantly(P0.05).Theleveloffastingplasmaglucose(FPG),2hoursplasmaglucose(2hPG)andglycohemoglobin(HbAIc)decreasedobviouslyinxuezhikanggroup(P0.05).Conclusions

6、Theseresultsindicatedthatxuezhikangiseffectiveinreducinghyperlipemia,improvingimpairedglucosetolerance,anditissafe.Therefore,xuezhikangismuchmoresuitableforthetreatmentofpatientswithhyperlipemiaandimpairedglucosetolerance,itisworthtobewidelyusedclinically.【Keywords】Lipid-regulatingtreatmentHyper

7、lipemiaImpairedglucosetolerance随着社会生活水平的提高，血脂异常的发生率呈逐年上升趋势，血脂偏高会引起高血压、糖尿病、脑卒中和冠心病等疾病，而慢性非传染性疾病已经成为危害社区居民身体健康的一大杀手。一些高脂血症的患者常合并有糖代谢紊乱等代谢综合症的症状，如糖耐量（IGT）异常，后者是导致糖尿病、心脑血管疾病的危险因素，其集簇发生可能与胰岛素抵抗有关。本文通过对157例高脂血症合并糖耐量异常的患者用不同的调脂治疗方案