尼可地尔对老年急性冠脉综合征患者经皮冠状动脉介入治疗术后血管内皮功能及炎性因子的影响

《尼可地尔对老年急性冠脉综合征患者经皮冠状动脉介入治疗术后血管内皮功能及炎性因子的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20153148中国图书分类号R541.1HebeiMedicalUniversity硕士学位论文专业学位尼可地尔对老年急性冠脉综合征患者经皮冠状动脉介入治疗术后血管内皮功能及炎性因子的影响研究生：李璇璇导师：李拥军教授专业：内科学二级学院：河北医科大学第二医院2018年3月目录中文摘要································································································

2、···········1英文摘要··········································································································2英文缩写···········································································································4研究论文尼可地尔对老年急性冠脉综合征患者经皮

3、冠状动脉介入治疗术后血管内皮功能及炎性因子的影响前言···········································································································5材料与方法·····························································································8结果······················

4、···················································································11附表··········································································································13讨论····························································

5、··············································15结论··········································································································19参考文献·······························································································

6、···19综述尼可地尔在冠心病患者中的应用进展··············································23致谢··················································································································31个人简历································································

7、··········································32中文摘要尼可地尔对老年急性冠脉综合征患者经皮冠状动脉介入治疗术后血管内皮功能及炎性因子的影响摘要背景：随着经皮冠状动脉介入治疗和抗血小板聚集药物的广泛应用，PCI术已成为老年急性冠脉综合征（acutecoronarysyndrome，ACS）患者血液循环重建的重要手段，但也因术中术后血栓脱落造成远端血管栓塞或边支血管闭塞，引起各种严重心肌缺血缺氧性损伤。目的：探讨尼可地尔对老年ACS患者PCI术后血管内皮功能及c反应蛋白(

8、CRP)水平的影响。方法：选取心内科收治的老年ACS患者90例，随机分为尼可地尔组和对照组。所有患者均于术前ld、术后1d、1个月检测内皮素(ET)一l、一氧化氮(NO)及CRP变化。结果：治疗前尼可地尔组和对照组血清CRP、NO、ET-1水平无明显差异(P>0.05)，与术前1d比较，两组患者术后ldNO水平降低，ET-1和CRP水平升高；术后1个月NO水平升高，ET-1和CRP水平降低(P<0.