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1、AbstractAbstractIntracerebralhemorrhage(ICH)isaseriousdiseasethathashighmortality，disabilityandfatalityratiowithouteffectivetreatment.SoitisstillahotpointtoresearchthetreatmentsofICH.Brainedemaisoneoftheimportantfactorsofitshighmortality.Increasedtheproductionoffreeradicalsisrep
2、ortedtohavecloserelationshipwithbrainedema,andeventurallycausesthedeathofneurons.NervousexcitotoxicityinducedbyEAAscouldcauseacuteorchroniccelldamageandcelldeath.ThedisequilibriumbetweenEAAsandIAAscouldcausebrainhistologiclesion.InflammatoryreactionwasalsodiscoveredinICH,cytokin
3、easanimportantinflammatoryfactor.playsaimportantroleinpathogenesisofICH.Accordingly，tokeepthekineticequilibriumbetweenfreeradicals,EAAsIAAs,andtoinhibitetheoverexpressionofcytokineisadomainwhichwearegoingtoopenuptotreatpathobolismlesionofICH.Rencentlyithasconsiderablecurativeef
4、fecttotreatcerebrovasculardiseasewithbaicalin.It’sreportedthatbaicalinhasmuchbiologicalfunction,suchasprotectingendotheliocyte,togettingridoffreeradicals,decreasingcerebralischemia-inducedneuroninjury,andsoon.However,studyonprotectivemechanismofbaicalinonICHwasseldomreported.Rat
5、modelofintracerebralhemorrhagewasinducedbycollagenasemethod.Theratswererandomlydividedintoshamoperationcontrolgroup,modelgroup,high，middleandlowdosedruggroup.Aftertreatment,toobserveprotectionofbaicalinonICH,thebrainwatercontentandthelevelofSOD，MDA,NOandNOSweremeasured，andthemor
6、phologywasalsoobserved.Atthesametime,thelevelofGluandGABAanditsmetabolicenzyme,GADandGABA-T,weredetermined,andtheexpressionofcytokine,TNF-αandIL-1β,weredetected.Theresultswereasfollowing:IIITheProtectionofBaicalinonBrainfollowingExperimentalIntracerebralHemorrhageinRats1.Thebrai
7、nwatercontentandthelevelofSOD，MDA,NOandNOSweremeasured,andthemorphologywasobservedindifferentgroups:Comparedwiththeshamoperationcontrolgroup,thebrainwatercontentandthelevelofMDA,NOandNOSweresignificantlyhigher,andthelevelofSODwassignificantlylowerinmodelgroup,Thebrainwaterconten
8、tandthelevelofMDA,NOandNOSweresignificantlylowe
