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1、AbstractAbstractIntracerebralhemorrhage(ICH)isaseriousdiseasethathashighmortality，disabilityandfatalityratiowithouteffectivetreatment.SoitisstillahotpointtoresearchthetreatmentsofICH.Brainedemaisoneoftheimportantfactorsofitshighmortality.Increasedtheproductiono
2、ffreeradicalsisreportedtohavecloserelationshipwithbrainedema,andeventurallycausesthedeathofneurons.NervousexcitotoxicityinducedbyEAAscouldcauseacuteorchroniccelldamageandcelldeath.ThedisequilibriumbetweenEAAsandIAAscouldcausebrainhistologiclesion.Inflammatoryre
3、actionwasalsodiscoveredinICH,cytokineasanimportantinflammatoryfactor.playsaimportantroleinpathogenesisofICH.Accordingly，tokeepthekineticequilibriumbetweenfreeradicals,EAAsIAAs,andtoinhibitetheoverexpressionofcytokineisadomainwhichwearegoingtoopenuptotreatpatho
4、bolismlesionofICH.Rencentlyithasconsiderablecurativeeffecttotreatcerebrovasculardiseasewithbaicalin.It’sreportedthatbaicalinhasmuchbiologicalfunction,suchasprotectingendotheliocyte,togettingridoffreeradicals,decreasingcerebralischemia-inducedneuroninjury,andsoo
5、n.However,studyonprotectivemechanismofbaicalinonICHwasseldomreported.Ratmodelofintracerebralhemorrhagewasinducedbycollagenasemethod.Theratswererandomlydividedintoshamoperationcontrolgroup,modelgroup,high，middleandlowdosedruggroup.Aftertreatment,toobserveprotect
6、ionofbaicalinonICH,thebrainwatercontentandthelevelofSOD，MDA,NOandNOSweremeasured，andthemorphologywasalsoobserved.Atthesametime,thelevelofGluandGABAanditsmetabolicenzyme,GADandGABA-T,weredetermined,andtheexpressionofcytokine,TNF-αandIL-1β,weredetected.Theresults
7、wereasfollowing:IIITheProtectionofBaicalinonBrainfollowingExperimentalIntracerebralHemorrhageinRats1.ThebrainwatercontentandthelevelofSOD，MDA,NOandNOSweremeasured,andthemorphologywasobservedindifferentgroups:Comparedwiththeshamoperationcontrolgroup,thebrainwate
8、rcontentandthelevelofMDA,NOandNOSweresignificantlyhigher,andthelevelofSODwassignificantlylowerinmodelgroup,ThebrainwatercontentandthelevelofMDA,NOandNOSweresignificantlylowe
