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1、氟比洛芬酯注射液与术后镇痛研究四川省宜宾市第二人民医院麻醉科644000【摘要】目的:观察氟比洛芬酯注射液在手术前超前镇痛应用对腹部手术后镇痛的影响与安全评价。方法:选择ASAI-II级腹部外科手术患者80例,随机双盲分为实验组和对照组,每组40例。实验组术前、术毕时分别应用氟比洛芬酯注射液lml/kg缓慢静脉注射,术毕镇痛泵内应用芬太尼0.5mg加牛理盐水至lOOrnlo对照组术毕镇痛泵内应用芬太尼lmg加牛理盐水至100mlo分別记录术后4、8、12、24h的视觉模拟评分(VAS)和不良反应及芬太尼的用量。结果:术后4、8、12h实验组的VAS评分明显低于对照组(P&
2、lt;0.05),术后24h无显著性差异,芬太尼用量实验组明显少于对照组(P&t;0.05),PCIA按压次数及不良反应无显著性差异。结论:氟比洛芬酯注射液超前镇痛对腹部手术后镇痛效果确切,减少了芬太尼的用量,不良反应发生率少。【关键词】氟比洛芬酯注射液;腹部手术;术后镇痛FlurbiprofeninjectionandpostoperativeanalgesiaHeChangyouLiuLianBoSecondPeople'sHospitalofYibinCity,SichuanProvinee,DepartmentofAnesthesiology(644000)Abs
3、tract:Objective:Observationofflurbiprofeninjectionapplicationofpreemptiveanalgesiabeforesurgeryanalgesiaafterabdominalsurgeryontheimpactandsafetyassessment-Methods:SelectASAI-IIgradeabdominalsurgeryin80patientswhoserandomlydividedintoexperimentalgroupandcontrolgroup40cases.Experimentalgro
4、upbeforeandafteroperationapplicationflurbiprofen,respectivelylml/kgslowintravenousinjection,aftersurgery0.5mgfentanylanalgesiapumpplussalineto100ml.Controlgroupaftersurgerylmgfentanylanalgesiapumpplussalineto100ml.4,8,12,24haftersurgerywererecordedVASandadversereactions,andfentanylamount.
5、Results:4,8,12haftersurgerytheexperimentalgroupVASscoresweresignificantlylowerthanthecontrolgroup(P<0.05),after24htherewasnosignificantdiffereneeinfentanylconsumptionwassignificantlylessthantheexperimentalcontrolgroup(P<0.05),PCIApressingfrequencyandsideeffectsnosignificantdifferenc
6、e.Conclusion:Flurbiprofeninjectionpreemptiveanalgesiaontheexactanalgesiaafterabdominalsurgery,reducingtheamountoffentanyl,asmallincidenceofadversereactions.Keywords:Flurbiprofeninjection;Abdominalsurgery;Postoperativeanalgesia【中图分类号]R323.3【文献标识码】A【文章编号】2096-0867(2016)-07-001-02氟比洛芬酯注射液是一种
7、以脂微球为载体的具有靶向镇痛作用的非笛类抗炎镇痛药,其到达炎症部位后通过抑制前列腺素合成,并降低脊髓、中枢的敏感性,从而减少痛觉冲动,发挥镇痛效应⑴,在国外多作为手术后的单次镇痛和癌痛的治疗,本研究拟评价氟比洛芬酯超前镇痛对腹部全麻术后镇痛效果的影响。1对象和方法(SubjectsandMethods)研究对象选择ASAI-II级腹部外科手术患者80例,其中男性44例,女性36例,年龄36〜68岁,平均年龄(52±6)岁。体重46〜90kg,平均体重(68±9)kg。患者既往无过敏史、消化道溃疡、血