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1、为了适应公司新战略的发展，保障停车场安保新项目的正常、顺利开展，特制定安保从业人员的业务技能及个人素质的培训计划阿扎胞苷-技术总结(共2篇) AcOHNOHNNNSiOAcNH2SiMol.Wt.: NNMol.Wt.: 2ONHMol.Wt.:Wt.: NH2NNN NaOMeNAcOHOMe 3 Mol.Wt.:Wt.: 步骤1操作程序： Ina22L,3-neckedflask,amixtureof5-azacytosine(1)(kg,mol,molareq.),HMDS(kg)andammoniumsulfate(g)washeatedatrefl
2、uxfor2hours.Afreshamountofammoniumsulfate(g)wasadded,andtherefluxwascontinuedfor6hourslonger.Theinitialslurryturnedintoaclear,pale-yellow,solutionandnomoregasevolvedattheendofthereflux.TheexcessHMDSwasevaporatedoffinvacuumtoobtainanoff-whiteresidue,whichistrimethylsilylated5-azacytosine. 步
3、骤2操作程序：目的-通过该培训员工可对保安行业有初步了解，并感受到安保行业的发展的巨大潜力，可提升其的专业水平，并确保其在这个行业的安全感。为了适应公司新战略的发展，保障停车场安保新项目的正常、顺利开展，特制定安保从业人员的业务技能及个人素质的培训计划 Trimethylsilylated5-azacytosine(6)preparedaccordingtothemethodofExample1wasdilutedwithanhydrousdichloromethane(kg)ina50L,3-necked,flaskandsolid,1,2,3,5-Tetra-O-ace
4、tyl-β-D-ribofuranose(kg,mol)(7)waschargedtothemixture.Ananhydrousdichloromethanerinse(kg)wasusedandtheslurrywascooledto0-5℃.TMS-triflate(kg,molareq.)wasaddedtothemixtureover5-10minutes.Duringtheaddition,thereactiontemperature目的-通过该培训员工可对保安行业有初步了解，并感受到安保行业的发展的巨大潜力，可提升其的专业水平，并确保其在这个行业的安全感。为了适
5、应公司新战略的发展，保障停车场安保新项目的正常、顺利开展，特制定安保从业人员的业务技能及个人素质的培训计划 increasedto15-20℃.andtheinitialsuspensionturnedintoaclear,pale-yellow,solution.After2hoursofstirring,thesolutionWaspouredoveramixtureofNa2C03(kg),NaHC03(kg),water(kg)andice(kg).Thelayerswereseparated.Thewaterlayerwasextractedwithdichlor
6、omethane(kg).Thecombinedorganicswerewashedwithcold(0-5℃.)10%NaHC03(2xl0L).Thecombinedwashingswereextractedwithdichloromethane(kg).Thecombinedorganicswerewashedwithcoldwater(2x5kg),driedonMgS04(kg),andfiltered.Thefiltrateanddichloromethanewashesonthepad(kg)werecombinedandreducedinvolumeusing
7、vacuum(-200mmHg,30℃).Thedistillationwascontinueduntilthemajorityofdichloromethane(app.85-95%total)wasremoved.Theresiduewastakenupinmethanol(kg)andtheremainingdichloromethanewasremovedtogiveaprotected5-azacytidine(8)asanoff-whitetoyellowfoam. 步骤3操作程序： P
