87例肾淀粉样变的临床病理研究

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1、上海交通大学硕士学位论文amyloidprecursorwasfibrinogen.Anti-fibrinogenstainingwasonlylocalizedinglomerulusandwasabsentintubulo-interstitialarea.Conclusions:1.Thisstudyof87patientsofrenalamyloidosisisthebiggestinChina.Primaryamyloidosisisthemostrecognizedtypewithclinicalmanifestationof

2、proteinuriaandnephroticsyndrome,occasionallyassociatedwithhypertensionandhematuria.Somepatientshavehypotension.Patiensinthestageofrenalfailurestillhavemassiveproteinuriaandnormalrenalsize.2.54.7%ofpatientshaveamonoclonalproteindetectedinserumimmunoelectrophoresis.16.9%ofp

3、atientshadALamyloidosisassociatedwithMM.Medianplasmocytepercentagewas2.5%inpatientsofprimaryamyloidosiswithoutMM.Congoredstainingisoneofpathologicalmethodstodiagnoseamyloidosis.Potassiumpermanganatetest,anti-AAstaining,anti-lightchainstainingandelectronmicroscopystudyfaci

4、litatethediagnosisofamyloidosis.4.Furtherimmunohistochemicalstudyofspecifictypeisessentialforpatientswithnegativeanti-lightchainstaining.KeyWords:renalamyloidosis,familialrenalamyloidosis,multiplemyeloma,congoredstaining上海交通大学硕士学位论文缩略语表（以字母先后为序）缩写英文全称中文AAAmyloidA血清淀粉样蛋白AA

5、β2MAmyloidBeta2-microglobulinβ2微球蛋白相关淀粉样变ALAmyloidLightChain轻链型淀粉样蛋白AApoAIAmyloidApolipoproteinAI载脂蛋白AI型淀粉样变AApoAIIAmyloidApolipoproteinAII载脂蛋白AII型淀粉样变ALysAmyloidLysozyme溶菌酶型淀粉样变AFibAmyloidFibrinogen纤维蛋白原型淀粉样变CKDChronicKidneyDisease慢性肾脏病DABDimethylaminoazobenzene二甲基氨基偶氮苯F

6、APFamilialAmyloidPolyneuropathy家族性淀粉样多发性神经病FRAFamilialRenalAmyloidosis家族性肾脏淀粉样变性GFRGlomerularFiltrationRate肾小球滤过率HCDDHeavyChainDepositionDiesease重链沉积病HEHematoxylin/Eosin苏木精/伊红IgImmunoglobin免疫球蛋白LCLightChain轻链LCDDLightChainDepositionDiesease轻链沉积病MonoclonalImmunoglobulinDep

7、ositionMIDD单克隆免疫球蛋白沉积病DiseaseMMMultipleMyeloma多发性骨髓瘤MPMelphalan/Prednisone马法兰/泼尼松RARheumatoidArthritis类风湿性关节炎TTRTransthyretin甲状腺激素结合蛋白VADVincristine/adriamycin/dexamethasone长春新碱/阿霉素/地塞米松WMWaldenströmMacroglobulinemia瓦氏巨球蛋白血症上海交通大学硕士学位论文上海交通大学学位论文原创性声明本人郑重声明：所呈交的学位论文，是本人在导

8、师的指导下，独立进行研究工作所取得的成果。除文中已经注明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要贡献的个人和集体，均已在文中以明确方式标明。