蝙蝠葛酚性碱对原代培养大鼠皮层细胞及离体脑片氧糖剥夺损伤的保护作用及机制研究

《蝙蝠葛酚性碱对原代培养大鼠皮层细胞及离体脑片氧糖剥夺损伤的保护作用及机制研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号学号D200978068学校代码10487密级博士学位论文蝙蝠葛酚性碱对原代培养大鼠皮层细胞及离体脑片氧糖剥夺损伤的保护作用及机制研究申请人姓名：赵博学科专业：药理学指导教师：郭莲军教授答辩日期：2012年5月AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineNeuroprotectiveEffectsandMechanismsofPhenolicAlkaloidsfromMenispermumdauricumRhizomeonOxy

2、gen-GlucoseDeprivationInjuryinPrimaryRatCorticalCulturesandBrainSlicesPh.D.Candidate:ZhaoBoMajor:PharmacologySupervisor:Prof.GuoLian-junHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2012独创性声明本人声明所呈交的学位论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研

3、究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到，本声明的法律结果由本人承担。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在______年解密后适用本授权数。本论文属于不保密□。√（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年

4、月日目录缩略词······················································································································1中文摘要··················································································································3英文摘要··········································

5、········································································5前言··························································································································8第Ⅰ部分蝙蝠葛酚性碱对原代培养大鼠皮层细胞氧糖剥夺损伤的保护作用及机制研究一蝙蝠葛酚性碱对原代培养大鼠皮层细胞氧糖剥夺损伤的保护作用材料与方法······················

6、·············································································15结果···············································································································19讨论·······························································································

7、················24参考文献·······································································································25二蝙蝠葛酚性碱抗原代培养大鼠皮层细胞氧糖剥夺损伤的机制探讨(一)蝙蝠葛酚性碱对细胞培养液中谷氨酸含量的影响材料与方法·····································································