不同程度soahs患者腭咽肌病理形态的电镜观察

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1、transmissionelectronmiscroscopy(TEM)inpatientswithobstructivesleepapneahypopneasyndrome(OSAHS)，theroleoftheabovemuscleinOSAHSpathogenesiswasdiscussed．MaterialsandMethods1．PatientsThirty-eightpalatopharyngealmuscleofOSAHSpatientsreceivinguvulopalatopharygop

2、lasty(UPPP)selected，andfivepalataltumorpatientsreceivingresectionwithoutsnoringasthecontrolgroup．2．MethodsThirty-eightpalatopharyngealmuscleofOSAHSpatientsreceivinguvulopalatopharygoplasty(OSAHS)werecollectededinin-patientdepartmentofChineseMedicalUniversi

3、tyandfivepalataltumorpatientsreceivingresectionwithoutsnoringwerechosenasthecontrolgroup．ThepalatophryngealmusclefiberandthefeatureofchangesinmitochondrialmorphologywereobservedinTEM．3．StatisticalAnalysisThepercentagesofmusclediscordersandmitochondrialdege

4、nerationwereanalyzedusingSPSS17．0forchi—squaretest．ResultsInTEM，thepalatopharyngealmyofibrillarofmildOSAHSgroupWasregularlyarranged．TheZlineswerestraight，andthemostmistochondriastructureshowednormal．Inthemoderategroup，themyofibrillarweredisorganized，andthe

5、Zlineswereshortenedordistorted．ThemyofibrillarinseveregroupWasdisorganized，similartopoint—likeorflake，andtheZlinesandthestructuresofsarcomeresweredisppearered，Andorganelleweredisintegratedandmitochondriaweredisappearedsimilartoflocculent．Thereexistedobviou

6、sfattyinfiltrationinthepalatopharyngealmuscle．Allthechangesabovewerenotbeenseeninthenormalcontrolgroup．．Thestatisticalanalysisresultshowsthatthepathologicalchangesofpalatopharyngealmusclefiberandmitochondriainfourgroupsaresignificant(P<0．001)ConelusionThed

7、egreeofpatientswithOSAHSiscorrelatedwiththepathologicalchangesof4palatopharyngeal．Thefattyinfiltrationandpathologicalchangesofmusclemitochondriamaybeoneofthemechanismsofthepharyngealairwaysinkingduringsleep．KeywordsSleepapneahypopneasyndrome，obstructive；Pa

8、latopharyngealmuscles；Pathology；Transmissionelectronmiscroscope．·英文缩略语·6·论文·不同程度OSAHS患者腭咽肌病理形态的电镜观察刖吾阻塞性睡眠呼吸暂停低通气综合征(obstructivesleepapneahypopneasyndrome，OSAHS)是一种睡眠时上气道塌陷阻塞引起的呼吸暂停和通气不足、伴有打鼾、频繁发生血氧饱和度下降的疾病。O