ra患者血清il-17水平检测与其意义的分析

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1、RF一样成为反映RA病人炎症活动的新指标之一。同时它还是侵蚀性关节损害的一个重要标志和危险因素，可导致关节结构破坏及功能低下，并提示患者预后不良。关键词：RAIL．17GPICRPRF3StudyofclinicalsignificanceofconcentrationdetectingofIL-17inserumsofpatientswithRAMasterdegreecandidate：LiuShutingSupervisor：ZhangXiaopingMajor：RheumatologyAbstraetBackground：Rheumatoidarthritis(RA)isakindo

2、fchronicautoimmunediseasethatmainlyinvolvesmalljoints．it’Spathologicalfeaturesareinvasionofinflammatorycells，proliferationandthickeningofsynovialmembrane，andinjuryofboneandcartilage．MostoftheinvasiveinflammatorycellsareTcells，oneofwhichisCD4+TeellthatcouldsecreteIL-17．NowhighconcentrationofIL一17has

3、beenfoundinsynovialfluid，synovialcellsandserum，however，thestudiesofcliniealsignificanceofIL-17inRAarerarelyseen．Objective：ToexplorethefunctionandclinicalsignificanceofIL一17withabnormalexpressionintheserumsofRApatients，SOastoprovideanewclueforRAdiagnosis．Methods：84serumsamplesofRApatientscomingfromt

4、heoutpatientandinpatientoftheSecondAffiliatedHospitalofDaLianMedicalUniversityincluding32malesand52females，rangingfrom27to70yearsoldwiththeaverageagesof49．60+10．69，Meanwhilesomeclinicaldatawerecollectedincludingage，courseofdisease，timecourseofmorningstiffness，numbersoftendernessandswellingandpainfu

5、ljoints．BesidesactiveandinactivephasesweredividedaccordingtothecriteriaofRApatientcondition；moreover，40serumsamplesofhealthypersonsfrommedicalexaminationcentrewhoseageandsexwereinaccordancewiththatoftheRApatientswerealsocollected．ELISAwasusedtoassaytheconcentrationlevelofIL．17inallserumsamples，andr

6、atenephelometrywasappliedtoassaytheconcentrationlevelsofCreactiveprotein(CRP)andrheumatoidfactor(RF)inRApatientserums．ELISAwasalsoexertedtoassaythelevelofglucose··6·-phosphateisomerase(GPI)andanti·cycliceitrullinatedpeptide(Anti—CCP)antibodyintheserums40fRApatientsIndependent—samplesTTestwasusedtoc

7、omparethelevelSofIL-17betweenRApatientsandhealthypersons；andbetweenactiveandinactivephases．PearsonCorrelationCoefficientwasusedtodetectthecorrelationbetweenIL-I7andGPI，CRP,RF，Anti-CCPantibody，andthecorrelat