多指标联合检测对菌阴肺结核的诊断价值

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1、万方数据英文摘要TheValueofCombinedDetectionofMultipleIndicesforDiagnosisofCultureNegativeTuberculosisABSTRACTTuberculosis，amajorinfectiousdiseasewhichendangersoverallhumanity,iSacrucialissueofpublichealthandseriOUSsocialproblem．China，followingIndia，confirmedthesecondlargestTB⋯infectedpopulationinthewor

2、ld．TuberculosisiSachronicinfectiousdiseasecausedbyMycobacteriumtuberculosis，withrespiratorydropletsastheprinciplemediaoftransmission．BacteriologicalexaminationofTBisamajormeansofidentifyingthesourcesofTBinfection．aswellastheimportantbasisforTBconfirmationandchemotherapyregimens．Culturenegativet

3、uberculosis，accountingforabout40％．60％ofalltheTBdiagnosis，iSclassifiedasanactiveTBwithnegativetypebasedontherespectivedetectionsofsputummycobacteriumandsputumsmearacidfastbacilli．Duetothehiddensymptomsofculturenegativetuberculosis，somepatiemsmayconverttosmear-一poSltlVepulmonarytuberculosis，ifthe

4、yfailtogettimelydiagnosisandtreatment。Thekeytotheeffectivediagnosisandtreatmentoftuberculosisisearlydiscovery,earlydiagnosis，andearlytreatmentwithearlydiagnosisonthetop．Nowadays，therearemultiplemethodsofTBdiagnosis：thechestimagingdetection，bacteriologyinspection，immunologicaldiagnosis，cytokines

5、detection，moleculardiagnosis，andetc．asthecommonelinicalpractices．Buteachofthesemethodshascertainlimitations，resultinginthefailureoftimelyandpromptdiagnosisofculturenegativetuberculosis．Culturenegativetuberculosisisalwayssubjectedtomisdiagnosisormisseddiagnosisduetothelackofconclusiveevidenceofb

6、acteriologicalexamination，merelybasedonsuchgeneralanalysisasmedcNhistory,symptoms，chestX-ray,chestCT，laboratoryexamination，andetc．Therefore，thediagnosisofculturenegativetuberculosisundergoesconsiderabledimculties．Withthedevelopmentoflaboratoryexaminationtechnology,thediscoveryandapplicationofva

7、rious万方数据英文摘要diagnosticmethodscarlimprovetheearlydiagnosisofculturenegativetuberculosisObjective：ToinvestigatethevalueofdeterminationofDNAfromMycobacteriumtuberculosis(TB．DNA)obtainedfromthesputumorbronchoalveolarlavagefluidsubjec