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ID:33010460
大小:2.57 MB
页数:59页
时间:2019-02-19
《胡椒碱对大鼠局灶性脑缺血的神经保护作用》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、英文摘要Another32maleSDratsweretreatedassameasitdescribedabove.Alloftheanimalwereperfusedwith4%paraformaldehydeinO.1mol/Lphosphatebufferat24hafterMCAO.Thebrainswereremovedfromtheskull,postfixed24hoursinthesamefixativeandthensectionedinto2.mmcoronalsliceanteriortoopticchiasma.Af
2、terparaffinembedding,theconsecutivesectionswereusedtodetectedapoptosisbyTUNELmethodandexpressionofcaspase一3byimmunohistochemistrytechnologyinthepenumbraregion.Thedatawasdescribedwithmean4-standarddeviation(x士s).Multiplecomparisonsofthedatawereanalyzedbymulti—sampleOne-WayAN
3、OV久andSNK-qtest.ItwastakenasthesignificantdifferencewhenP<0.05.Results:1.Neurologicdefectappearedinthesaline,vehicleandpiperinegroupratafterMCAO.Therewasnoneurologicimpairmentintheshamedgroup.Therewasnosignificantdifferenceat2hafterMCAOamongthreeofthesaline,vehicleandpiperi
4、negroupp>0.05).TheNeurologicaldeficitscoresofpiperinegroupwassignificantimprovedcomparedwithitofsalineandvehiclegroupat24h,48hand72hafterMCAO眵5、16士15.43)mm3inpiperinegroup.Therewasnosignificantdifferencebetween5荚文摘要——————————————————————————————————————一thesalinegroupandvehiclegroupp>0.05).itwasfoundthatobviousdifferenceofinfarctedvolumesbetweenpiperinegroupandsalinegrouporvehiclegroup(p<0.01).3.Thecountofapoptosis6、cellsinsalinegroup,vehiclegroupandpiperinegroupwere52.70-a:6.15,48.58+7.17and20.30-士2。67,respectively.TheapoptosiscellsdecI.easeddramaticallyinpiperinegroup(p<0.01).4.ThecountofCaspase一3postivecellswere21.30土3.20.22·15+2.57and11.68+1.96insalinegroup,vehiclegroupandplpennegr7、ouprespectively.Therewasnosignificantdifferencebetweenthesalinegroupandvehiclegroupp>0.05).TheCaspase-3postivecellsdecreaseddramaticallvinpiperinegroupp8、otectiveeffectonacuteischemicbraininjuryinrats.2.Thepiperinecaninhibittheapoptosis
5、16士15.43)mm3inpiperinegroup.Therewasnosignificantdifferencebetween5荚文摘要——————————————————————————————————————一thesalinegroupandvehiclegroupp>0.05).itwasfoundthatobviousdifferenceofinfarctedvolumesbetweenpiperinegroupandsalinegrouporvehiclegroup(p<0.01).3.Thecountofapoptosis
6、cellsinsalinegroup,vehiclegroupandpiperinegroupwere52.70-a:6.15,48.58+7.17and20.30-士2。67,respectively.TheapoptosiscellsdecI.easeddramaticallyinpiperinegroup(p<0.01).4.ThecountofCaspase一3postivecellswere21.30土3.20.22·15+2.57and11.68+1.96insalinegroup,vehiclegroupandplpennegr
7、ouprespectively.Therewasnosignificantdifferencebetweenthesalinegroupandvehiclegroupp>0.05).TheCaspase-3postivecellsdecreaseddramaticallvinpiperinegroupp8、otectiveeffectonacuteischemicbraininjuryinrats.2.Thepiperinecaninhibittheapoptosis
8、otectiveeffectonacuteischemicbraininjuryinrats.2.Thepiperinecaninhibittheapoptosis
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