三七总皂苷肠溶微丸的制备及药代动力学研究

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1、学校代码：10600学号：091110学位类型：科学学位广西中医药大学硕士学位论文三七总皂苷肠溶微丸的制备及药代动力学研究研究生：文丽导师：刘华钢教授院系（部所）：药学院专业：中药学研究方向：中药新制剂与新剂型研究完成日期：2012年4月1日目录中文摘要········································································1英文摘要·······························································

2、·········3引言·········································································5正文·········································································9第一部分PNS肠溶微丸（胶囊）的制备······························91PNS体外分析方法的建立······································91.1材

3、料与仪器································································91.2方法与结果·································································102PNS的PH值、溶解度及表观油水分配系数的测定和PNS初步稳定性考察·········································································172.1材料与仪1器····

4、··························································172.2方法与结果·································································172.3小结与讨论································································203PNS肠溶微丸（胶囊）处方和制备工艺研究···········223.1PNS微丸丸芯的制备工艺研究·······

5、·····································223.1.1材料与仪器···························································223.1.2方法与结果·······························································223.1.3小结与讨论·······························································303.2PNS肠

6、溶衣包衣工艺的研究···············································303.2.1材料与仪器···························································303.2.2方法与结果·······························································303.2.3小结与讨论·····················································

7、··········363.3PNS肠溶微丸（胶囊）的药剂学性质考察·································363.3.1粒度·····································································2··363.3.2休止角·····································································363.3.3堆密度······························

8、·······································363.3.4临界相对湿度的测定····················································363.3.5颗粒吸湿百分率··········