小鼠播散性巨细胞病毒感染的免疫应答和致病机制研究1)小鼠脾巨噬细胞dna感受器aim2识别mcmv dna激活其炎性体通路的整体研究;2)th17细胞在急性播散性 mcmv感染致病机制中的作用

《小鼠播散性巨细胞病毒感染的免疫应答和致病机制研究1)小鼠脾巨噬细胞dna感受器aim2识别mcmv dna激活其炎性体通路的整体研究;2)th17细胞在急性播散性 mcmv感染致病机制中的作用》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号学号D200978329学校代码10487密级博士学位论文小鼠播散性巨细胞病毒感染的免疫应答和致病机制研究1）小鼠脾巨噬细胞DNA感受器AIM2识别MCMVDNA激活其炎性体通路的整体研究2）Th17细胞在急性播散性MCMV感染致病机制中的作用学位申请人：李旭芳学科专业：儿科学指导教师：方峰教授答辩日期：2012年5月AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineTheStudiesonImmuneResponsesandPathogenes

2、isofMicewithDisseminatedMurineCytomegalovirusInfection:1)RecognitionofMCMVDNAbyAIM2asDNAsensorandactivationofAIM2inflammasomepathwayinspleenmacrophagesofmicewithdisseminatedMCMVinfectioninvivo2)RolesofTh17cellsinthepathogenesisoftheacutedisseminatedMCMVinfectionD.Candidate:LiXufangMajor:Pediatric

3、sSupervisor:FangFengHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2012独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留

4、并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日基金项目——教育部博士点基金项目《CMV激活天然免疫细胞dsDNA感受器相关炎性体通路对抗CMV免疫的指导作用》，项目编号：2009014211007目录缩略词表···········································

5、·································1中文摘要············································································3英文摘要············································································7前言··········································································13一、小鼠脾巨噬细胞DNA感受器AIM2识别MC

6、MVDNA激活其炎性体通路的整体研究··················································20材料和方法·································································21结果····································································29讨论····································································33参考文献·······

7、·····························································37二、Th17细胞在急性播散性MCMV感染致病机制中的作用实验一MCMV体外诱导Th17细胞分化方法的探索··················40材料和方法·································································40结果·········