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1、中国细胞生物学学报ChineseJournalofCellBiology2013,35(6):852–856http://www.cjcb.orgDOI:10.11844/cjcb.2013.06.0025综述胰岛发育相关的转录因子邢小娟效梅丹慧国安立龙*(广东海洋大学农学院动物科学系,湛江524088)摘要影响胰岛发育的转录因子有Mnx1(motorneuronandpancreashomeobox1)、Pdx1(pan-creaticandduodenalhomeobox1)、Ngn3(neurogen
2、in3)、Grg3(groucho-gene-relatedgene3)、Nkx2.2(NK2homeodomain2)、Nkx6.1(NK6homeodomain1)、MafA(v-mafmusculoaponeuroticfibro-sarcomaoncogenehomologA)等。在这些转录因子中,Pdx1对胰芽形成、β细胞成熟以及维持β细胞正常功能起关键作用;Ngn3促使胰腺祖细胞向内分泌细胞分化;Mnx1、Nkx2.2、Grg3保证β细胞的表型,抑制β细胞分化为α细胞;Nkx6.1调节β细胞的增
3、殖和分化;MafA具有β细胞特异性,在胰岛素合成、分泌和糖代谢过程中起重要作用。转录因子异常与糖尿病的发生有着非常密切的关系。因此,探讨这些转录因子在胰岛发育中所起的作用对糖尿病的治疗有重要意义。关键词胰腺内分泌祖细胞;胰岛;分化;转录因子;糖尿病TranscriptionFactorsRelatedtoIsletDevelopment_XingXiaojuan,XiaoMei,DanHuiguo,AnLilong*x±s(DepartmentofAnimalScience,AgriculturalColl
4、ege,GuangdongOceanUniversity,Zhanjiang524088,China)AbstractThedevelopmentofisletisregulatedbyseveraltranscriptionfactors:Mnx1(motorneuronandpancreashomeobox1),Pdx1(pancreaticandduodenalhomeobox1),Ngn3(neurogenin3),Grg3(groucho-gene-relatedgene3),Nkx2.2(NK2
5、homeodomain2),Nkx6.1(NK6homeodomain1),MafA(v-mafmusculoaponeuroticfibrosarcomaoncogenehomologA)andsoon.Amongthesetranscriptionfactors,Pdx1playsacriticalroleintheformationofpancreaticbud,βcellmaturationandmaintenanceofβcellfunction;Ngn3expressiondrivespancr
6、e-aticprogenitorstowardsendocrinecells;Mnx1,Nkx2.2,Grg3ensureβcellphenotype,inhibitingthedifferentiationofβcellstoαcells;Nkx6.1regulatestheproliferationanddifferentiationofβcells;MafAisβcell-specificandplaysanimportantroleinthesynthesisandsecretionofinsuli
7、nandglycometabolism.Abnormaltranscriptionfac-torshaveaverycloserelationshipwiththeincidenceofdiabetes.Therefore,toexploretheroleofthesetranscrip-tionfactorsduringisletdevelopmentisimportanttothetreatmentofdiabetes.Keywordspancreaticendocrineprogenitors;isl
8、et;differentiation;transcriptionfactor;diabetes脊椎动物胰岛由α、β、ε、PP及δ细胞组成,其收稿日期:2013-01-17接受日期:2013-03-12中,α细胞分泌胰高血糖素(glucagon)、β细胞分泌胰广东省自然科学基金(批准号:20100915)资助的课题*通讯作者。Tel:0759-3239127,E-mail:anlilong@126.com岛素(in
