rsk4在人体正常组织的分布及其在肾细胞癌中的表达和功能的初步研究

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1、分类号密级公开国际十进分类号（UDC）第四军医大学博士学位论文RSK4在人体正常组织的分布及其在肾细胞癌中的表达和功能的初步研究范林妮培养类别学历研究生申请学位类型学术学位学科(领域)专业病理学与病理生理学指导教师黄高昇教授指导教师单位基础部病理学与病理生理学教研室二O一二年五月独创性声明秉承学校严谨的学风与优良的科学道德，本人声明所呈交的论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其他人已经发表或撰写过的研究成果，不包含本人或他人已申请学位或其他用途使用过的成果。与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确

2、的说明并表示了致谢。申请学位论文与资料若有不实之处，本人承担一切相关责任。论文作者签名：日期：保护知识产权声明本人完全了解第四军医大学有关保护知识产权的规定，即：研究生在校攻读学位期间论文工作的知识产权单位属第四军医大学。本人保证毕业离校后，发表论文或使用论文工作成果时署名单位仍然为第四军医大学。学校可以公布论文的全部或部分内容（含电子版，保密内容除外），可以采用影印，缩印或其他复制手段保存论文。学校有权允许论文被查阅和借阅，并在校园网上提供论文内容的浏览和下载服务。同意学校将论文加入《中国优秀博硕士学位论文全文数据库》和编入《中国知识资源总库》，同意按《中国优秀博硕士学位论文全文数据库出版章

3、程》规定享受相关权益。论文作者签名：导师签名：日期：RSK4在人体正常组织的分布及其在肾细胞癌中的表达和功能的初步研究研究生：范林妮学科专业：病理学与病理生理学所在单位：第四军医大学病理学与病理生理学教研室导师：黄高昇教授辅导教师：王哲教授资助基金项目：国家自然科学基金青年基金（81001140）关键词：组织芯片；免疫组织化学；RSK4；肾细胞癌；生存分析；预后；细胞周期；Transwell中国人民解放军第四军医大学二O一二年四月第四军医大学博士学位论文目录缩略语表·································································

4、····················1中文摘要·····················································································4英文摘要·····················································································9前言···················································································15文献回顾········

5、···········································································17正文···················································································36第一部分应用组织芯片研究RSK4在人体正常及肿瘤组织的表达·······361.材料··············································································361.1组织芯片·······

6、·······························································361.2主要仪器和试剂·····························································371.3主要工作液···································································382.方法··············································································383

7、.结果··············································································394.讨论··············································································44第二部分RSK4在肾细胞癌中的表达及与患者预后的关系·······