合并cmbs的t2dm患者相关记忆功能及静息态脑功能改变的分析

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1、万方数据biochemistry’relatedmaterial．A1lthepatientswereexamedbytraditionalmagneticresonanceimaging、FunctionalMagneticResonanceImagingandsusceptibilityweightedimaging．whitematterhyperintensities、Lacunarinfarctionandcerebralmicrobleedswereobserved．ByfMRIana

2、lysis、functional—connectivityanalysisandALFFanalysis，wegetabnormalbrainareasintype2diabetesmellituspatients．Atlast，wemadecorrelationanalysisbetweenabnormalbrainareasandimpairedcognitionfunction。Results：1Amongallpatients，theCMBspositivewasobservedin34p

3、atientswhiletheCMBsnegativewasobservedin58patients．Theincidenceratewas36．96％．2Cognitivefunction：WhenComparedwiththepatientswhohadnoCMBs，thescoresofWMSmemoryquotient，workingmemoryandshort-timememorywaslowerintype2diabetesmellituspatientswithCMBs．(P<0．0

4、5)3Functionalconnectivity：Wecarriedoutanalysisbetweenbilateralhippocampalandallothervolexstodeterminetheregionswithlow—frequencyfluctuationsthatandcorrelatedwithit．Theresultsshowedthathippocampusshowedreducedfunctionalconnectivitybilaterallytowidespre

5、adregions，includingleftTemporalPole，leftsuperiortemporalgyms，fightanteriorcingulategyrusandfightPrecentralGymsintype2diabetesmellituspatientswithCMBscomparedtotype2diabetesmellituspatientswithoutCMBs．Moreover，thefunctionalconnectivitybetweenlefthippoc

6、ampalandleftsuperiortemporalgymswerefoundtobepositivelyrelatedtoshort-termmemory(imagination)intype2diabetesmellituswithCMBsgroup(r=O．29，p=O．034)，andthefunctionalconnectivitybetweenrighthippocampalandrightanteriorcingulategymswerefoundtobepositivelyre

7、latedtoworking--memory(WMS1--100)intype2diabetesmellituswithCMBsgroup(r=0．25，p=0．039)．4Two-samplet-testanalysis，type2diabetesmellituswithCMBspatientshadsignificantlydecreasedALFFvaluesintheleftsuperiorfrontalgyms；whereasincreasedALFFvalueswereobserved

8、inleftsuperiortemporalGyms、boththebilateralcerebellumposteriorlobeandthefightInsula．FurthermoretheALFFvalueintheleftsuperiortemporalGymswasfoundtobecorrelatedpositivelywithtotalmemory(WMSmemoryquotientcore)(r=O．26，p=0．045)．V万方数据Conclusions：The