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时间:2019-02-26
《血浆同型半胱氨酸浓度与2型糖尿病视网膜病变的关系》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、维普资讯http://www.cqvip.com巾山科杂志20(}2年1月第4I卷第l期ChinJInlemM。dJ⋯2002.Vol4I.No.论著血浆同型半胱氨酸浓度与2型糖尿病视网膜病变的关系杨国庆陆菊明潘长玉【摘要】目的观察空腹血浆总同型半胱氨酸(Hc~)水平与2型糖尿病视网膜病变发生发展的关系方法研究对象为55倒2型糖碌病【DN)和19例(男l2倒,女7倒)非DM健康对照者(CON)。DM组分为两个亚组:无微血管并发症(NDC)组39倒(男l7例.女22例).糖尿病视网膜病变lDR)组16例(男8倒.女8例J。所有患者肾功能和尿白蛋白/肌酐LAlb/Crj
2、均正常。根据跟底荧光造影判断视网膜病变的严重程度应用高效液相一反相色谱分析和荧光检测的方法删定空腹血浆Hcv水平=结果DR组、NDC组和CON组间的血浆总Hey浓度差异有显著性lF=2405,P=0031),DR组血浆总Hcy水平[:147±528)Vmld/L显著高于NDC组113:4.94)gmob/L]和CON组[(965=266)!tmol/L]。NDC组与∞组比较差异无显著性。在DR组.增殖性视网膜病变(PDR)亚组总Hcy水平显著高于背景性视网膜病变(BDR)亚组(c=2405,P=003I)率研究中.总Hey超过l497mol/L即为高同型半胱氨酸血症
3、,其中PDR亚组有4倒,BDR亚组为I例结论伴视网膜病变的2型DM患者血浆总Hey水平高于正常』、,其中PDIt组的血浆总HcY浓度高于BDR组空腹血浆同型半胱氨酸水平可能是2糖尿病视网膜病变的重要危险因素之一。【关键词】高半胱氢酸;糖尿病视网膜病;糖尿病.非胰岛素依赖型Theimpactofplasmahomocysteinelevelondevelopmentofrelinopathyintype2diabetmdlitus)ANGGg,LL:Jaming,PANChangy~DepartmentofEndocrinology,GeneralHospitalof
4、thePIA,Beil'ing100853,China【A自slracl】ObjectiveAⅡinereasedplasmabetllOCyst㈣ileve1isanimportantriskfac【0⋯fo]ardiseaseinthegeneralpopulationHowever,theroleofhypedmmocysteinendainthedevelopmentoftype2diabeticretinopathy(DR)isstillunknownTherefore.oaimstodeterminetherelationshipbetweenthefa
5、stingplasmahomoeysteine(Hcvlevelsandthepresenceofdiabefemfinopathyinpatientswithtype2diabetes.MethodsThestudygroupconsistedof55㈣softype2diabeticpatients【DM);19healthypersonsservedascontrol(CON,12menand7women)TheDblgroupsubdividedintoagroupwithoutdiabeticcomplications(NDC.39cas.17menand
6、22'e,,OltlenjandagroupwithDRc16E.8tllenand8womenJTheretmlfunctionandtheratioofalbmnir~creatidineAlb.'Cr)werewithinnomm]rangeinallthesubjectsThepresenceandthegradeofretinopathydetemfinedbyanophthalmologistPlasmatotalHey(tHcy)w,92~mea日Lbyaotonmtedhigh—perfommneeliquidehromatogeaphy(HPLC)
7、withreverseptu~seseparafiotand~uocescenf2edetectionResultsPlasmatHe}'levelswecesignifleantlydiferentamongDR、NDCandCONgroups(F=2405,P=0031)PlasmatotalHeysigaificantlyhighel*ittDRgroupl(14.7±528)gnml,.'L]thaninNDC[f11.3±494)!maol/L.andCONgroup[(965±2.66)gmd/LJTherewasnodiferencebetween
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