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1、中国肿瘤临床·1411·乳腺癌患者血清可溶性肿瘤标志物的临床价值研究①赵晶刘红张爱敏顾林乳腺癌防治教育部重点实验室天津市肿瘤防治重点实验室天津医科大学附属肿瘤医院乳腺科（天津市300060）摘要目的：探讨血清可溶性肿瘤标志物CEA、CA-153、ICAM-1、E-selection单项及联合检测在乳腺癌中的诊断价值。方法：选取不同临床分期乳腺癌患者130例，乳腺良性肿瘤患者30例，正常人群30例，通过酶联免疫吸附法（ELISA）测定各项指标血清浓度并进行比较。结果：乳腺癌CEA、CA-153、I
2、CAM-1、E-selection血清浓度均显著高于良性肿瘤组及正常人群（P<0.01），且其血清浓度与肿瘤分期密切相关。在疾病进展的转移性乳腺癌中，各指标出现明显升高（P<0.01）。CEA、CA-153、ICAM-1、E-selection单项检测对于乳腺癌的诊断敏感性较低，多指标联合检测可不同程度提高检测的敏感性，以含CA-153及E-selection组合最为显著。结论：E-selection、ICAM-1、CEA、CA-153均为乳腺癌重要的血清标志物，在肿瘤的发生、发展及转移过程中发
3、挥重要的作用。对恶性肿瘤患者的多指标联合检测可在不显著降低特异性的基础上提高诊断的敏感性，为判断预后及监测病情提供重要价值。关键词乳腺癌肿瘤标志物CEACA-153ICAM-1E-selectinTheSignificanceofDetectingSerumSolubleTumorMarkersforPatientswithBreastCancerZHAOJing,LIUHong,ZHANGAimin,GuLinCorrespondingauthor:LIUHong,E-mail:ezxwm@1
4、63.comDepartmentofBreastCancer,CancerInstituteandHospitalofTianjinMedicalUniversity,Tianjin300060,Chi-naObjective:ToinvestigatetheclinicalvalueofdetectingserumlevelsofCEA,CA-153,ICAM-1,andE-se-lectinforpatientswithbreastcarcinoma.Methods:Usingchemilu
5、minescentimmunoassay,wedetectedtheserumlevelsofCEA,CA-153,ICAM-1andE-selectinin130patientswithbreastcancer,30patientswithbe-nignbreasttumorsand30healthycontrolsubjects.Results:TheserumlevelsofCEA,CA-153,ICAM-1,andE-selectininthebreastcancergroupweres
6、ignificantlyhigherthanthoseinthebenignbreastdiseasegroupandthecontrolgroup(P<0.01).Inthebreastcancergroup,thelevelsofthesetumormarkerswereincreasedasthemalignantdegreeincreasedandwereremarkablyhigherinpatientswithmetastasis(P<0.01).Thecom-bineddetect
7、ionofthesefourmarkershadahighersensitivitythantheindependentdetectionofeachmarker.ThesensitivityofcombineddetectionofCA-153andE-selectinwasthemostsensitive.Conclusion:E-se-lectin,ICAM-1,CEA,andCA-153areimportanttumormarkersofbreastcancerandmayplayasi
8、gnificantroleinthedevelopmentandmetastasisofbreastcancer.E-selectin,ICAM-1,CEA,andCA-153canbeusedastumormarkersinthediagnosisofbreastcancerandmaybeofgreatvalueinassessingpatientconditionandpredictingprognosis.KeywordsBreastcancer;Tumormarker;CEA;CA-1
