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1、中华医学检验杂志1996年11月第19卷第6期·343·血清载脂蛋白参考值王抒李健斋赵淑华唐蔚青褚德发李培瑛满咏李红霞摘要目的调查健康中、老年人载脂蛋白(apo)AI、AÊ、B、CI、CÊ、CË、E及脂蛋白(a)[Lp(a)]的参考值,分析各项血脂与apo之间的相关。方法严格选择生活水平一般的北京健康居民,男225人,女58人,年龄38～83岁(大都在45～70岁间)。血脂测定用标准化方法,apoAI、B参考血清的定值符合WHO国际标准。除Lp(a)与apoCI测定用ELISA法外,其他各项apo分析均用免疫透射比浊法。结果统计得
2、各项apo的均数与百分位数分布并与国内外资料比较。相关分析显示Lp(a)与apoCI是独立的变量,与年龄、体重及各项血脂均无明显相关。其他各项血脂与apo指标可以分为3组,分别代表高密度、低密度与极低密度脂蛋白水平。分析了体重指数、甘油三酯与高密度脂蛋白的相互关系。结论apoAI、B测定中采用了WHO国际参考血清后结果比以往的报告有明显提高。其他apo测定尚未开始标准化研究,但作者所列参考值大致与用同类方法所报告的数据近似。14项血脂之间的相关分析,有助于研究有关代谢问题及临床上实验指标的合理选用。关键词载脂蛋白参考值Refere
3、ncevaluesofserumapolipoproteinsWangShu,LiJianzhai,ZhaoShuhua,etal.Bei2jingInstituteofGeriatrics,BeijingHospital,Beijing100730AbstractsObjectivesToinvestigatetheeferencevaluesofapoAI,AÊ,CIÉÊ,CË,Eandlipoprotein(a)ofmiddleagedandoldsubjects,andtostudythecorrelationsbetwe
4、envari2ouslipidparameters.MethodsAfterthoroughphysicalandlaboratoryexamination,225maleand58femalehealthyBeijingresidents(aged38-83,mostly45-75yearsold)withmoderatelivingstandardwereselected.Serumtotalcholesterol(TC),lipoproteincholesterol(HDL-CandLDL-C)andtriglyceride
5、(TG)wereanalyzedwithwellstandardizedmethods.AssignedvaluesofapoAI,BofserumcalibratorswereprovedtobetrceabletothetargetvaluesofWHOinternationalreferencematerials.Mostaposweredeterminedbyimmunoturbidimetricmethods,butLp(a)andapoCIweredeterminedbyELISAmethod.ResultsAvera
6、geapoBlevelswere1.01göLinmenand1ö07göLinwomen,thecorrespondingTCandLDL-Cvalueswere4.87and2.95mmolöLinmen,and5.16and3.13mmolöLinwomenrespectively.MeanapoAIlev2elswere1.42göLinmenand1.45göLinwomen,andthecorrespondingHDL-Cwas1.41and1.54mmolöL.TheproportionofHDL2-CandHDL3
7、-Cwasapproximately4:6.ThemeanandmediumvaluesofLp(a)inmaleswere144and107mgöL,infamaleswere154and117mgöL.Themeanandthepercentiledistributionoftheaposstudiedwerelistedindetail.CorrelationanalysisrevealedthatLP(a)andapoCIwereindependentvariables.Otherparame2tersweredivide
8、dinto3groups;theymainlyrepresentedthelevelsofHDL,LDL,andVLDL.BodymassindexwasnegativelycorrelatedwithHDL-C,andpositivelycorr
