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1、BrainedemaandcerebrovascularpermeabilityduringcerebralischemiainratsSHatashitaandJTHoffStroke1990;21;582-588StrokeispublishedbytheAmericanHeartAssociation.7272GreenvilleAvenue,Dallas,TX72514Copyright©1990AmericanHeartAssociation.Allrightsreserved.PrintISSN:0039-
2、2499.OnlineISSN:1524-4628Theonlineversionofthisarticle,alongwithupdatedinformationandservices,islocatedontheWorldWideWebat:http://stroke.ahajournals.orgSubscriptions:InformationaboutsubscribingtoStrokeisonlineathttp://stroke.ahajournals.org/subscriptions/Permiss
3、ions:Permissions&RightsDesk,LippincottWilliams&Wilkins,adivisionofWoltersKluwerHealth,351WestCamdenStreet,Baltimore,MD21202-2436.Phone:410-528-4050.Fax:410-528-8550.E-mail:journalpermissions@lww.comReprints:Informationaboutreprintscanbefoundonlineathttp://www.lw
4、w.com/reprintsDownloadedfromstroke.ahajournals.orgbyonNovember22,2010582BrainEdemaandCerebrovascularPermeabilityDuringCerebralIschemiainRatsShizuoHatashita,MD,andJulianT.Hoff,MDFocalcerebralischemiawasproducedbyoccludingtheleftmiddlecerebralarteryin769rats.Perme
5、abilityoftheblood-brainbarriertosmallorlargemoleculeswasevaluatedqualitativelyusingEvansblueorsodiumfluoresceinandquantitativelyusingthetransferindexesofMiodine-125-labeledbovineserumalbuminor[C]sucrose.Watercontentwasdeterminedusingwetanddryweightsandsodiumandp
6、otassiumcontentsusingflamephotometry.Corticaltissueinthemiddlecerebralarteryterritorywassampled<14daysafterocclusion.Asignificantincreaseinthealbumintransferindexwasfirstfound12hoursafterocclusion,andtheindexremainedapproximatelythesameuntilwatercontentpeaked3da
7、ysafterocclusion.Incontrast,thesucrosetransferindexincreasedgradually,significantlycorrelatedwithincreasesinthewaterandsodiumcontents.TissuestainingbysodiumfluoresceinwasmoreextensivethanthatbyEvansblue.Asedemafluiddecreasedgradually4-10daysafterocclusion,thealb
8、uminandsucrosetransferindexesincreasedmarkedly.Thesefindingsindicatethatdisruptionoftheblood-brainbarriertosmallmoleculesisaccompaniedbyaccumulationofedemafluidduring
