施他林联合可利新治疗食管胃底静脉曲张破裂大出血的临床研究

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1、临床外科杂志2006年8月第14卷第8期JClinSurg,August2006,Vol.14,No.8·501··论著·施他林联合可利新治疗食管胃底静脉曲张破裂大出血的临床研究朱峰邹声泉[摘要]目的研究施他林联合可利新在处理食管胃底静脉曲张破裂引发重度上消化道出血时的疗效。方法74例肝硬化合并重度上消化道出血患者随机分为3组:施他林联合可利新组26例;单用施他林组24例;单用可利新组24例。结果三组病例总止血率分别为96.2%、72.7%和70.8%(P<0.05);平均出血时间分别为(8.66±4.92)h、(13.47±9.02)h和(13.58±8.35)h(P<0

2、.05);输血量分别为(869.23±403.75)ml、(1172.72±513.79)ml和(1250.00±599.27)ml(P<0.05);总病死率分别为3.8%、27.3%和29.2%(P<0.05)。结论施他林联合可利新治疗肝硬化并发重度上消化道出血在近期止血率和总止血成功率方面明显优于单用施他林或可利新,具有止血迅速、疗效肯定、安全可靠等优点。[关键词]食管胃底静脉曲张;重度上消化道出血;施他林;可利新[中图分类号]R575.2[文献标识码]A[文章编号]100526483(2006)0820501203Combineduseofstilaminewithg

3、lypressininthetreatmentofmajorhemorrhageofup2perdigestivetractZHUFeng,ZOUSheng2quan.(DepartmentofGeneralSurgery,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTech2nology,Wuhan430030,China)[Abstract]ObjectiveTostudythetherapeuticeffectivenessofstilaminecombinedwithglypre

4、ssinintreatingmajorhemorrhageofupperdigestivetractcausedbyesophagealandgastricfundusvaricosis.MethodsSeventy-fourcaseswerechosenfromthepatientswhowerediagnosedashepaticcirrohsisassociatedwithmajorhemorrhageofupperdigestivetract.Theywereallocatedrandomlyinto3groups:combinedtreatmentgroup(26

5、cases);stilamine-treatedgroup(24cases)andglypressin-treat2edgroup(24cases).ResultsInthecombinedtreatmentgroup,stilamine-treatedgroupandgly2pressin-treatedgroup,thewholehemostaticratesin3groupswere96.2%,72.7%and70.8%respec2tively(P<0.05);themeanbleedingtime(h)8.66±4.92,13.47±9.02and13.58±8.

6、35respective2ly(P<0.05);thetransfusionvolume(ml)869.23±403.75,1172.72±513.79and1250.00±599.27respectively(P<0.05);thetotalmortalityrates3.8%,27.3%and29.2%respectively(P<0.05).ConclusionStilaminecombinedwithglypressintreatingmajorhemorrhageofuppergastroin2testinaltractcausedbyesophagealandg

7、astricfundusvaricosisismoreeffectivethanusingstilamineorglypressinaloneinhemostaticratesofearlyperiod,andithasthecharacteristicsoffasthemostasis,safetyandreliability.[Keywords]esophagealandgastricfundusvaricosis;majoruppergastrointestinaltracthemorrhage;stilam