BMP-2在大鼠喙侧迁移流的发育学表达及其对SVZa神经干细胞体外分化调控的初步研究

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1、第三军医大学硕士学位论文常用英文缩写一览表英文缩写英文名称中文名称bFGFBasicfibroblastgrowthfactor碱性成纤维细胞生长因子BMP-2Morphogeniticproteins-2骨形成蛋白2BMPRsMorphogeniticproteinsreceptors骨形成蛋白受体GCLGranulecelllayer颗粒细胞层EPLExternalplexiformlayer球周细胞层BMPsMorphogeniticproteins骨形成蛋白CNSCentralnervoussystem中枢神经系统DADopaminergic多巴胺能DMEMDulbec

2、co’smodifiedeaglemedium改良的基础培养基GABAGamma-aminobutyricacidg-氨基丁酸GFAPGlialacidicfibrillaryprotein胶质细胞纤维蛋白hHour小时LVLateralventricle侧脑室MMol摩尔minMinute分钟mRNAMessengerRNA信使RNANestinNeuroepitheliastemcellprotein神经上皮干细胞蛋白NFNeurofilament神经元NGFNervegrowthfactor神经生长因子NSCsNeuronstemcells神经干细胞OBOlfactory

3、bulb嗅脑球PBSPhosphatebufferedsaline磷酸盐缓冲液RMSRostralmigratorystream喙侧迁移流rpmRollperminute每分钟转数Reversetranscriptionpolymerasechain逆转录多聚酶链反应RT-PCRreactionSecSecond秒1第三军医大学硕士学位论文SmadSam-motheragainstdppSam-mad蛋白SVZaAnteriorsubventricularzone,室管膜前下区TGF-Transforminggrowthfactor-转化生长因子THTyroxinehydrox

4、ylase酪氨酸羟化酶2第三军医大学硕士学位论文TheExpressionsofBMP-2inRostralMigratoryStreamofDevelopingRatBrainanditsEffectsontheDifferentiationandRegulationsofSVZaNeuralStemCellsinvitroAbstractWiththelucubratingstudiesonneuralstemcells(NSCs),theanteriorsubventricularzone(SVZa)asaspecialareawhereNSCsareconcentrat

5、edhasbeenfocusedbymoreandmorereseachers.NSCsderivedfromSVZanotonlypossessthecharacteristicsofNSCs,butalsohavetheirownfeatures:1)theywillmigrateformSVZatoolfactorybulb(OB)alonganespecialrouteway-therostralmigratorystream(RMS)aftertheyareproduced;2)theywillmaintainproliferatingandthecharacters

6、ofneuralprogenitor;3)theydifferentiateintomaturatedneuronswhilemigratingtodestinationandbecometherenewingresourceofOBinterneuronsinthewholelifeofmammalanimals,whichistheuniquecharacterofSVZaNSCsdifferedfromotherNSCs.However,thedevelopmentofSVZaNSCsareaffectednotonlybyinheritgenes,butalsobyth

7、eextracellularsignals.Recently,therewereincreasingevidencesthatmanyextracellularsignalsregulatetheproliferationanddifferentiationofNSCs,suchasmitogenicfactors(EGF),transcriptionfactors(BMPs,Mash1,Pax6,andWnt)andsoon.Increasingevidencessuggestedthat