大环化合物的关环策略

《大环化合物的关环策略》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、RingClosureMethodsintheSynthesisofMacrocyclicNaturalProductsQingchangMengiandManfredHesseInstituteofOrganicChemistry,UniversityofZurich,Winterthurcrstrasse190,CH-8057Zurich,SwitzerlandTableofContents1Introduction...........................1092MethodsInvolvingLactonization..................1

2、112.1TheCoreyMethod.....................11t2.2TheMukaiyamaMethod..................1142.3TheMasamuneMethod...................1162.4MixedAnhydrideMethods..................1182.5CyclizationMediatedbytheMitsunobuReaction........1222.6CyclizationMediatedbyCarbodiimide.............1242.7Activated

3、EsterMethods...................1252.8CyclizationMediatedbyOrganotinReagents..........1272.9OtherMethods.......................1282.10Stereochemistry,AnotherImportantFactor..........1303MethodsInvolvingLactamization..................1333.1MixedAnhydrideMethods..................1333.2Activate

4、dEsterMethods...................1373.3TheMukaiyamaMethod..................1393,4KeteneTrappingMethod..................1403.5Boron-TemplateMethod...................1413.6OtherMethods.......................1424MethodsInvolvingC-CBondFormation..............1434.1NucleophilicAdditiontoCarbonyls

5、..............1434.2Alkene-AcetalCoupling...................1484.3AlkylationofCarbanionsorEnols..............1491PartofthePh.D.thesisofQ.M.,Zurich1991TopicsinCurrentChemistry,Vol.161©Springer-VerlagBerlinHeidelberg1991Q.MengandM.Hesse4.4PinacolandRelatedReactions................1534.5Free-R

6、adicalMacrocyclization................1544.6Nickel-MediatedCyclization.................1554.7Bis-ArylHalideCoupling..................1564.8OtherMethods.......................1575MethodsInvolvingC=CBondFormation..............1615.1Wittig-LikeReactions....................1625.2TheMcMurryMetho

7、d....................1626MethodsInvolvingEtherFormation.................1636.1Alcohol-HalideCoupling...................1636.2Alcohol-DithioketalCoupling................t636.3DiphenolCoupling.....................1647MethodsInvolvingAmineFormation.........