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1、蚌埠医学院学报2009年6月第34卷第6期473[文章编号]100022200(2009)0620473204·临床医学·肾上腺髓质素在肺癌患者中的表达及作用111111234温雪萍,李艳,王忠慧,彭清,颜志军,丁梅芬,黄绍光,赵家美,苏宝山[摘要]目的:探讨肾上腺髓质素(adrenomedullin,ADM)在肺癌患者的表达及其与肺癌临床生物学特征的相关性。方法:采用免疫组织化学和放免法检测肺癌组织及血浆中ADM的表达情况,并回顾性分析ADM基因表达与肺癌的临床生物学特征的关系。结果:肺癌组织的ADM蛋白表达明显高于癌旁组织及正常肺组织(P<
2、0.01),而癌旁组织的ADM阳性表达率与正常肺组织差异无统计学意义(P>0.05)。肺癌组织中ADM蛋白的表达与肺癌分化程度有一定关系(P<0.05),与年龄、病理类型和TNM分期无明显关系(P>0.05)。肺癌组血浆中ADM含量均高于非肺癌组和健康对照组(P<0.05和P<0.01),且血浆中ADM的表达与TNM分期有一定关系(P<0.05),与病理类型无明显关系(P>0.05)。结论:肺癌患者中ADM表达明显增强,其表达水平与肺癌分化程度显著相关,ADM基因在肺癌的发生、发展中可能起重要作用。[关键词]肺肿瘤;肾上腺髓质素[中国图书资料分
3、类法分类号]R734.2[文献标识码]AExpressionandroleofadrenomedullininhumanlungcancer111111WENXue2ping,LIYan,WANGZhong2hui,PENGQing,YANZhi2jun,DINGMei2fen,234HUANGShao2guang,ZHAOJia2mei,SUBao2shan(1.DepartmentofRespirtoryDisease,MinhangHospitalofRuijinHospitalGroup,Shanghai201100;2.Departm
4、entofPulmonology,RuijinHospital,SchoolofMedicine,ShanghaiJiaotongUniversity,Shanghai200025;3.DepartmentofPulmonology,ShanghaiChestHospital,Shanghai200030;4.DepartmentofOncology,TheSecondAffiliatedHospital,MedicalSchoolofXi′anJiaotongUniversity,ShangxiXi′an710004,China)[Abstr
5、act]Objective:Toinvestigatetheexpressionofadrenomedullin(ADM)inhumanlungcancerandtoevaluateitsclinicalsignificance.Methods:ImmunohistochemicalstainingwasperformedtoexaminetheexpressionofADMinlungcancer,radioimmunoassaywasappliedtodeterminetheconcentrationofADMintheplasmofpat
6、ientsandcontrols,andtherelationshipwasretrospectivelyanalyzedbetweentheexpressionofADMinlungcancerandtheclinicobiologicalfeatures.Results:TheexpressionofADMinlungcancerwassignificantlyhigherthanthoseinadjacenttissuesandnormaltissues(P<0.01),andthepositiverateofADMproteininad
7、jacenttissuesandthatinthenormaloneswasnosignificantdifference(P>0.05).TherewasasignificantrelationshipbetweentheexpressionofADMandthegradeoflungcancer(P<0.05andP<0.01),andtherewerenorelationshipsbetweentheexpressionofADMandage,histologicaltypeandTNMstage(P>0.05).Theexpressio
8、nofADMintheplasmoflungcancergroupwassignificantlyhigherthanthoseintheplasmo
