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1、现代中西医结合杂志ModernJournalofIntegratedTraditionalChineseandWesternMedicine2007Feb,16(6)#737#壳聚糖对2型糖尿病模型大鼠血糖、血脂、胆固醇含量的影响12王淑玲,黄金华(1.江苏省南通市口腔医院,江苏南通226001;2.南通大学医学院,江苏南通226001)[摘要]目的观察壳聚糖对链脲佐菌素(STZ)诱发的2型糖尿病模型大鼠血糖、血脂及血清胆固醇的影响。方法取SD大鼠50只,随机分为正常空白组、糖尿病模型对照组及壳聚糖治疗组、壳聚糖对照组及药物治疗
2、组,除正常空白组和壳聚糖对照组外其他各组均采用高能量饮食4周后加小剂量一次性腹腔注射STZ的方法建立2型糖尿病大鼠模型;每组大鼠在注射STZ后每2周1次尾静脉取血测空腹血糖、血清胆固醇和三酰甘油(TG)的含量。结果采用高能量饮食加STZ所诱发的2型糖尿病大鼠空腹血糖、血清胆固醇和TG明显高于正常对照组(P<0.05或0.01),壳聚糖可降低2型糖尿病模型大鼠的血糖、血清胆固醇和TG浓度,与模型组同期比较有明显改善(P<0.05或0.01),接近药物治疗组(P均>0.05);而壳聚糖对正常大鼠血糖无明显影响(P>0.05)。结论2
3、型糖尿病大鼠血糖增高可能引起血脂、血清胆固醇升高,壳聚糖能有效地降低2型糖尿病模型大鼠的血糖、血清胆固醇和TG浓度,改善2型糖尿病病变。[关键词]壳聚糖;2型糖尿病;血糖;血脂[中图分类号]R-332[文献标识码]A[文章编号]1008-8849(2007)06-0737-03Influenceofchitosanonbloodglucoseandserumlipoproteinlevelintype2diabetesrats12WANGShu2ling,HUANGJin2hua(1.NantongBuccalDiseaseHo
4、spital,Nantong226001,Jiangsu,China;2.MedicalCollegeofNantongUniversity,Nan2tong226001,Jiangsu,China)Abstract:ObjectiveItistoobservetheinfluenceofchitosanonbloodglucoseandserumlipoproteinindiabeticratsin2ducedbystreptozotocin(STZ).MethodsAllratswererandomlydividedinto
5、fivegroups:normalblankgroup,modelgroup,chitosancontrolgroup,chitosantreatmentgroupandmedicinetreatmentgroup.Besidesblankcontrolgroupandchitosancontrolgroup,otherswereestablishedastype2diabetesmodelbyhigh2energydietfor4weeksandlowerdoseinjectedwithintraperitonealSTZ.B
6、loodglucoseandserumcholesterolandtriglyceridce(TG)contentsinratsweredetectedtwoweeklyincaudalvenousbloodafterSTZinjection.ResultsThelevelsofbloodglucoseandserumcholesterolandTGofthediabeticmodelratsinducedbyenrich2dietandSTZwerehigherthanthoseofthenormalcontrolgroup(
7、P<0.05or0.01),chitosanCouldimprovedtheabovechanges,thoseweresignificantdeviationtocomparewiththemodelgroup(P<0.05or0.01),itwassamewithmedicinetreatmentgroup(P>0.05),andchitosanhavenonconspicuousinfluencedoverbloodglucosecon2tentsofthemodelgroup(P>0.05).ConclusionTheh
8、igherlevelofbloodglucoseintype2diabetesmodelratscanincreasethelevelsofserumlipoproteinandTG.Chitosanmayefficientlytreattype2diabete
