Laminin蛋白对UBM上BMSCs增殖与其向平滑肌细胞分化的影响

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1、万方数据第三军医大学硕士学位论文TheeffectsofLamininontheproliferationandSMCsdif]ferentiationfromBMSCsseededonUrinaryBladderMatrixBackgrOundandPurpose：AbstractStressurinaryincontinence(SUI)isacommondiseaseinolderwomen．It’sreportedthattheincidenceratewas27．6％intheolderwomen，furtheritaf．fectedseriouslythequalityo

2、f1ifeforthemajorityofwomen．IthascausedtheacademicattentioninObstetricsandGynecologythatSUIiscloselyrelatedtothechangesinstructuralofthepelVicsinf．emale．Surger)，isacommonmethodofthetreatmentofSUIandsuspensionsu略eryhasbecomethenrst．1inesurigicaltreatment．Atpresent，theslingmaterialinclinicalcontai

3、nssyntheticpolymers，thenaturalextracellularmatrixmaterialandacellularmatrixderiVatiVe，forexample，bladderextracellularmatrix，pigleatherandsmallintestinalsubmucosa，etcTheidealmaterialofthepelvicnoorrepairingshouldbesaf．e，durableandbiocompatiblescaff01dforcellsseededontheadhesionandgrowth．Itisnotu

4、sedwidelyintheclinic，becausethatsyntheticmaterialhasdisadVantageofstrongorganizationalerosionandscarringfDnning．Theacenularmatrixhasbeenwidelyusedintissueengineeringandregenerativemedicineduetothatitretainsintracellularprocessingoftissueintegrityandlowimmunogenicity．Asoneoftheacellularmatrix，re

5、liminarystudiesindicatesthatUBMhasthepotentialinthetreatmentofSUI，butthebiggestproblemisthatitisinabletocontroleffectivelythedegradationofthematerialandresultedtheSUIinrelapse．Inrecentyears，withthef．urtherdevelopmentofstemcellresearchandbio—engineeringtechn0109y，somescholarshasproposedthatthetr

6、ansplantationofstemcellmaybeanef．fectiVemeansofthetreatmentofSUI，theexperimentinanimalshasopenedupthenewdirectionsforthetreatmentofSUI．ThebonemarrowmesenchymalstemcellscoulddifrerentiateintosmoothmuscleceUsandendothelialcellsundercertainconditions，soastoachieVethepu印oseoftissuerepairing．TheUBMl

7、oadedBMSCshasthelowpr01iferationanddifferentiationintosmoothmusclecells，whichrestrictstheclinical印plication．Itisthefocusofresearchers2万方数据第三军医大学硕士学位论文thathowtoimprovetheprolif色rationofBMSCsanddin’erentiationintosmoothInusclecells．