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1、RESEARCHARTICLEAge-RelatedDisparityinImmediatePrognosisofPatientswithTriple-NegativeBreastCancer:APopulation-BasedStudyfromSEERCancerRegistries12111WenjieZhu,EdithA.Perez,RuoxiHong,QingLi,BingheXu*1DepartmentofMedicalOncology,CancerHospital,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCo
2、llege,Beijing,China,2MayoClinic,Jacksonville,Florida,UnitedStatesofAmerica*bhxu@hotmail.comAbstractBackgroundTriple-negativebreastcancer(TNBC)hasbeendemonstratedtocarrypoorprognosis,butOPENACCESSwhetherornotthereexistsanyage-relatedvariationinTNBCoutcomeshasyettobeeluci-dated.Thecurrentpopulati
3、on-basedstudyinvestigatedtheearlysurvivalpatternofelderlyCitation:ZhuW,PerezEA,HongR,LiQ,XuB(2015)Age-RelatedDisparityinImmediatePrognosiswomenwithTNBCandidentifiedoutcome-correlatedfactors.ofPatientswithTriple-NegativeBreastCancer:APopulation-BasedStudyfromSEERCancerRegistries.PLoSONE10(5):e01
4、28345.doi:10.1371/journal.pone.0128345PatientsandMethodsAcademicEditor:Shian-YingSung,TaipeiMedicalWesearchedtheSurveillance,Epidemiology,andEndResults(SEER)databaseanden-University,TAIWANrolledfemaleprimarynon-metastaticTNBCcases.Thepatientsweresubdividedintoelder-Received:December18,2014ly(7
5、0years)andyounggroups(<70years).ThesurvivalstatusofelderlypatientswasAccepted:April26,2015comparedtothatoftheyoungerwomen.Theprimaryandsecondaryendpointswerecan-cer-specificsurvival(CSS)andoverallsurvival(OS)respectively.Published:May28,2015Copyright:©2015Zhuetal.Thisisanopenaccessarticledistri
6、butedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsResultsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourceare9908femaleTNBCpatientsdiagnosedfrom2010to2011wereincludedinthecurrentcredited.study(20.4%elderly).Elderlypatientswithrelativel
7、yadvanceddiseasesexhibiteddistinctlyDataAvailabilityStatement:Allrelevantdataareworsecancer-specific(log-rank,p<0.001)andoverallsurvival(log-rank,p<0.001)thantheirwithinthepaper.youngcounterparts.Advancedageatdiagnosis(70years)wa
