Comprehensive Transcriptome Profiling Reveals Multigene Signatures in Triple-Negative Breast Cancer

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1、PersonalizedMedicineandImagingClinicalCancerResearchComprehensiveTranscriptomeProfilingRevealsMultigeneSignaturesinTriple-NegativeBreastCancer1,2,31,2,31,2,31,2,31,2,3Yi-RongLiu,Yi-ZhouJiang,Xiao-EnXu,XinHu,Ke-DaYu,and1,2,3,4Zhi-MingShaoAbstractPurpose:ByintegratingexpressionprofilesofmRNAsandlonglo

2、w-riskgroupinbothsignatures[HR,10.00;95%confidencenoncodingRNAs(lncRNA),wetriedtodevelopandvalidateinterval(CI),2.53–39.47,P¼0.001;HR¼4.46,95%CI,1.34–novelmultigenesignaturestofacilitateindividualizedtreatment14.91,P¼0.015forintegratedsignatureandmRNAsignature,oftriple-negativebreastcancer(TNBC)pat

3、ients.respectively).Resultswerevalidatedinthevalidationset(P¼ExperimentalDesign:Weanalyzed165TNBCsamplesand330.019and0.030,respectively).Inaddition,time-dependentpairednormalbreasttissuesusingtranscriptomemicroarrays.receiveroperatingcurveshowedthattheintegratedmRNA–Tumor-specificmRNAsandlncRNAswer

4、eidentifiedandcorre-lncRNAsignaturehadabetterprognosticvaluethanboththelatedwithpatients'recurrence-freesurvival(RFS).UsingCoxeight-mRNA-onlysignatureandtheclinicopathologicriskfactorsregressionmodel,webuilttwomultigenesignaturesincorporat-inbothsets.WealsofoundthroughinteractionanalysisthatingmRNA

5、sandlncRNAs.Theprognosticandpredictiveaccuracypatientsclassifiedintothelow-riskgroupbytheintegratedofthesignaturesweretestedinatrainingsetof165TNBCpatientsmRNA–lncRNAsignaturehadamorefavorableresponsetoandvalidatedinother101TNBCpatients.adjuvanttaxanechemotherapy.Results:WesuccessfullydevelopedanmR

6、NAandanintegratedConclusions:ThemultigenesignaturewedevelopedcanmRNA–lncRNAsignaturebasedoneightmRNAsandtwoaccuratelypredictclinicaloutcomeandbenefitoftaxanelncRNAs.Inthetrainingset,patientsinthehigh-riskgroupwerechemotherapyinTNBCpatients.ClinCancerRes;1–10.Ó2015morelikelytosufferfromrecurrentdise

7、asethanpatientsintheAACR.IntroductionsensitiveandspecificprognosticsignatureswouldbeofgreatvalueintheindividualizedtreatmentofTNBCpatients.Triple-negativebreastcancer(TNBC)isoneofthemostaggressiveWiththedevelopmen