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1、RESEARCHARTICLEIdentificationofaComprehensiveSpectrumofGeneticFactorsforHereditaryBreastCancerinaChinesePopulationbyNext-GenerationSequencing1,21,21,21,21,2XiaochenYang,JiongWu,JingsongLu,GuangyuLiu,GenhongDi,1,21,22,32,45CanmingChen,YifengHou,MenghongSun,WentaoYang,Xiaojing
2、Xu,52,62,61,22,4,71,2YingZhao,XinHu,DaqiangLi,ZhigangCao,XiaoyanZhou,XiaoyanHuang,1,22,32,32,61,21,2ZhebinLiu,HuanChen,YanziGu,YayunChi,XiaYan,QixiaHan,1,21,2,61,2ZhenzhouShen,ZhiminShao,ZhenHu*1DepartmentofBreastSurgery,ShanghaiCancerCenter,FudanUniversity,Shanghai,China,2D
3、epartmentofOncology,ShanghaiMedicalCollege,FudanUniversity,Shanghai,China,3TissueBank,DepartmentofPathology,ShanghaiCancerCenter,FudanUniversity,Shanghai,China,4DepartmentofPathology,ShanghaiCancerCenter,FudanUniversity,Shanghai,China,5Laboratoryofmolecularbiology,NationalEn
4、gineeringCenterforBiochipatShanghai,Shanghai,China,6KeyLaboratoryofBreastCancerinShanghai,ShanghaiCancerCenter,FudanUniversity,Shanghai,China,7InstituteofPathology,FudanUniversity,Shanghai,ChinaOPENACCESS*hzhenhu@yahoo.comCitation:YangX,WuJ,LuJ,LiuG,DiG,ChenC,etal.(2015)Iden
5、tificationofaComprehensiveSpectrumofGeneticFactorsforHereditaryBreastCancerinaChinesePopulationbyNext-GenerationAbstractSequencing.PLoSONE10(4):e0125571.doi:10.1371/journal.pone.0125571Thegeneticetiologyofhereditarybreastcancerhasnotbeenfullyelucidated.Althoughgerm-AcademicE
6、ditor:AlvaroGalli,CNR,ITALYlinemutationsofhigh-penetrancegenessuchasBRCA1/2areimplicatedindevelopmentofhereditarybreastcancers,atleasthalfofallbreastcancerfamiliesarenotlinkedtotheseReceived:November23,2014genes.Toidentifyacomprehensivespectrumofgeneticfactorsforhereditarybr
7、eastcancerAccepted:March24,2015inaChinesepopulation,weperformedananalysisofgermlinemutationsin2,165codingPublished:April30,2015exonsof152genesassociatedwithhereditarycancerusingnext-generationsequencingCopyright:©2015Yangetal.Thisisanopen(NGS)in99breastcancerpatientsfromfami
8、liesofcancerpatientsregardlessofcanceraccessarticledistributedundertheterms
