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Temperature-dependentstructurestabilityandInvitroreleaseofchitosan-coatedcurcuminliposomeYujiaLiu,DandanLiu,LiZhu,QianGan,XueyiLePII:S0963-9969(15)00187-8DOI:doi:10.1016/j.foodres.2015.04.024Reference:FRIN5786Toappearin:FoodResearchInternationalReceiveddate:29Januar
2、y2015Reviseddate:10April2015Accepteddate:12April2015Pleasecitethisarticleas:Liu,Y.,Liu,D.,Zhu,L.,Gan,Q.&Le,X.,Temperature-dependentstructurestabilityandInvitroreleaseofchitosan-coatedcurcuminliposome,FoodResearchInternational(2015),doi:10.1016/j.foodres.2015.04.024ThisisaPDFfileofan
3、uneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybe
4、discoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTTemperature-dependentstructurestabilityandInvitroreleaseofchitosan-coatedcurcuminliposomeaaaaa,b,*YujiaLiu,DandanLiu,LiZhu,QianGan,XueyiLeaDepartmentofAppliedChemistry,SouthChin
5、aAgriculturalUniversity,Guangzhou510642,ChinabInstituteofBiomaterial,SouthChinaAgriculturalUniversity,Guangzhou510642,ChinaABSTRACT:Liposome,apromisingdeliverysystemwithphospholipidbilayer,couldimprovethewatersolubilityofcurcumin,whichisapolyphenolicnaturalproductwithmanybioactivit
6、ies.However,theinstabilityofliposomelimitsitsdevelopmentinapplication.Inthisstudy,thechitosanwasusedtoprotectthestructurestabilityofphospholipidbilayerofcurcuminliposomeandcontrolthesustainedreleaserateofcurcuminfurther.Thetemperaturestabilityandphasetransitionwerestudiedbydifferen
7、tialscanningcalorimetry.Whencurcuminmoleculewasembeddedinphospholipidbilayer,thepre-transitiontemperature(50.40℃)andmainphasetransitiontemperature(61.47℃)decreasedabout10℃comparedtoitwithoutcurcumin,andphospholipidbilayerfluiditywasincreased.Thepre-transitiontemperaturewasdisappear
8、edafterchitosancoatedonthe
