加替沙星治疗社区获得性肺炎疗效观察【药学论文开题报告】

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1、药学论文-加替沙星治疗社区获得性肺炎疗效观察作者：李宏云秦超刘谦付群【摘要】目的探讨加替沙星治疗社区获得性炎的疗效及不良反应的发生。方法入选2005年2月1日至2006年1月31日我医院的CAP住院患者107例，随机分成A、B两组皿组(54例)给予生理盐水250m1+加替沙星400mg静脉滴注，qd，治疗14d；B组(53例)给予生理盐水100ml+头鞄咲辛2.0静脉滴注，ql2h，治疗14d。依据症状、体征、实验室检查恢复以及致病菌清除评价疗效；依据治疗前后肝、肾功能、血糖改变及恶心、呕吐消化道反应发生率评价不良反应。结果两组治

2、愈率分别为57.4%和54.7%，通过ridit检验，统计学无显著性差异；有效率分别为94.4%和88.7%，有显著性差异(P<0・05)；两组细菌清除率分别为88.9%和94.1%^无显著性差异(P>0.05)。两组治疗前后肝、肾功能、血糖改变及恶心、呕吐消化道反应发牛率均无统计学差异。结论应用加替沙星治疗CAP，能达到非常满意的临床效果与满意的细菌清除率，且不良反应发生率低，値得临床推广。【关键词】加替沙星社区获得f生肺炎临床疗效细菌清除率Observationofthetherapeuticeffectsofgatiflox

3、acinoncommunityacquiredpneumoniaABSTRACTObjectiveToinvestigatetheefficacyandadverseeffectsofgatifloxacinoncommunityacquicdpneumonia(CAP).MethodsOnehundredandseveneasesofCAPhospitalizedpatientswereselectedfromtheFifthAffi1iatedHospitaiofZhengzhouUniversity,from1stFeb,2

4、005to31stJan,2006・TheywererandomlydividedintogroupAandB.GroupA(54cascs),weretreatedwithnormalsaline(250ml)andgatifloxacin(400mg)intravenousdripperdayfor14days;GroupB(53cases),weretreatedwithnormalsaline(250ml)andcefuroximeintravenousdripper12hoursfor14days.Theefficaci

5、eswereevaluatedaccordingthetherapeuticindices,includingsymptom,sign,recoveryoflaboratoryexaminationandclearancerateofpathogenicbacteriaandtheadversereactionindices,includingtheshiftofliver,renalfundionsandbloodsugarpre/posttreatment,theoccurrenceofalimentarytractreact

6、ionssuchasnausea,vomiting.ResultsForgatifloxacinandcefuroxime,thecurerateofCAPwere57.4%and54.7%respectively,therewasnosignificantdifferencewithridittest.Theefficacyrateswere94.4%and88.7%respectivelywithsignificantdifferences(P<0.05).Theclearancerateofpathogenicbacteri

7、awere88.9%and94.1%respectively(P>0.05)・Nostatisticdifferencewasshownbetweenthetwogroupsforadversereactions.ConclusionSatisfactoryclinicalefficaciesandclearanceofpathogenscanbeachievedwithgatifloxacintherapyofCAPwithlowADRoccurrence・GatifloxacincouldbeusedforclinicalCA

8、Ptreatment・KEYWORDSGatifloxacin;Communityacquiredpneumonia;Clinicaltherapeuticeffects;Clearanceofpathogens获得性肺炎(CAP)是常见的社区感染