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1、加替沙星治疗社区获得性肺炎疗效观察作者：李宏云秦超刘谦付群【摘要】冃的探讨加替沙星治疗社区获得性肺炎的疗效及不良反应的发生。方法入选2005年2月1H至2006年1月31FI我医院的CAP住院患者107例,随机分成A、B两组。A组(54例)给予生理盐水250ml+加替沙星400mg静脉滴注,qd,治疗14d；B组(53例)给予生理盐水lOOmR头砲咲辛2.0静脉滴注，ql2h,治疗14do依据症状、体征、实验室检查恢复以及致病菌清除评价疗效；依据治疗前后肝、肾功能、血糖改变及恶心、呕吐消化道反应发生率评价不良反应。结果两组治愈率分别为57.4%和
2、54.7%,通过ridit检验，统计学无显著性差异;有效率分别为94.4%和88.7%,有显著性差异(P<O.05)；两组细菌清除率分别为88.9%和94.1%,无显著性差异(P>0.05)。两组治疗前后肝、肾功能、血糖改变及恶心、呕吐消化道反应发生率均无统计学差异。结论应用加替沙星治疗CAP,能达到非常满意的临床效果与满意的细菌清除率，且不良反应发生率低，值得临床推广。【关键词】加替沙星社区获得性肺炎临床疗效细菌清除率Observationofthetherapeuticeffectsofgatifloxacinoncommunit
3、yacquiredpneumoniaABSTRACTObjectiveToinvestigatetheefficacyandadverseeffectsofgatifloxacinoncommunityacquiedpneumonia(CA卩).MethodsOnehundredandsevencasesofCAPhospitalizedpatientswereselectedfromtheFifthAffiliatedHospitalofZhengzhouUniversity,from1stFeb,2005to31stJan,2006・They
4、wererandomlydividedintogroupAandB.GroupA(54cases),weretreatedwithnormalsaline(250ml)andgatifloxacin(400mg)intravenousdripperdayfor14days;GroupB(53cases),weretreatedwithnormalsaline(250ml)andcefuroximeintravenousdripper12hoursfor14days・Theefficacieswereevaluatedaccordingthethe
5、rapeuticindices,includingsymptom,sign,recoveryoflaboratoryexaminationandclearancerateofpathogenicbacteriaandtheadversereactionindices,includingtheshiftofliver,renalfunctionsandbloodsugarpre/posttreatment,theoccurrenceofalimentarytractreactionssuchasnausea,vomiting・ResultsForg
6、atifloxacinandcefuroxime,thecurerateofCAPwere57.4%and54.7%respectively,therewasnosignificantdifferencewithridittest・Theefficacyrateswere94.4%and88.7%respectivelywithsignificantdifferences(P&It;0.05).Theclearancerateofpathogenicbacteriawere88.9%and94.1%respectively(P>0.05)・
7、Nostatisticdifferencewasshownbetweenthetwogroupsforadversereactions・ConclusionSatisfactoryclinicalefficaciesandclearanceofpathogenscanbeachievedwithgatifloxacintherapyofCAPwithlowADRoccurrenee.GatifloxacincouldbeusedforclinicalCAPtreatment・KEYWORDSGatifloxacin;Communityacquir
8、edpneumonia：Clinicaltherapeuticeffects;Clearanceofpathogens获得性肺炎(CAP
