资源描述：
《脑梗死患者血小板参数的测定及临床意义》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、脑梗死患者血小板参数的测定及临床意义作者：简崇东，毕桂南，石胜良，谢姚屹【摘耍】目的检测脑梗死患者外周血的血小板参数，研究脑梗死发病后不同时间段及不同梗死面积的血小板参数变化，为临床应用抗血小板聚集治疗脑梗死提供理论依据。方法应用全自动血细胞分析仪,对97例脑梗死患者及40例健康体检者进行血小板参数(主要指血小板计数、血小板平均体积、血小板分布宽度)检测,按不同发病吋间段分为<48h内组(20例)、49h〜7d组(33例)、7〜14d天组(11例)，14d后组(33例)；按梗死面积不同分为腔隙性脑梗死组(39例)、小面积梗死组
2、(29例)、大面积梗死组(29例)o对各组与对照组间及各组Z间的血小板参数进行比较。结果脑梗死患者急性期外周血血小板计数(Pit)降低，血小板平均体积(MPV)、血小板分布宽度(PDW)升高。发病48h内Pit显著减少(P<0.01),7〜14d及>14d逐渐恢复正常(P>:0.05);发病48h内MPV及PDW显著升高(P<0.01),49h〜7d达高峰,Z后逐渐降低，但至14d后仍高于正常水平(P<0.05)。脑梗死面积越大，患者Pit越低(P<0.05),MPV、PDW越高(P<0.05
3、)。结论在动脉粥样硬化及脑梗死患者中动态监测血小板参数的变化，有助于脑梗死的预防及预后的判断。【关键词】脑梗死;血小板计数;血小板平均体积；血小板分布宽度AbstractObjectiveTostudytheregularityandsignificanceofthevariationsoftheplateletparametersincerebralinfarction(CI)duringdifferentperiodandinfarctsizeandprovidetheoreticalbasistheantiplateletag
4、gregationtreatment.Methods97caseswithcerebralinfarctionand40healthyparticipantsweredetectedthepla.teletparametersbyautomatichematologyanalyzer・Theyweredividedintofourgroupsbydifferentperiods(<48houTS,49h〜7days,7〜14daysand>:14days)anddividedintothreegroupsbytheinfa
5、rctsize(largesizesmal1sizeandlacunarCT)・ThestudyselectestheCTpatients(Cigroup)andthehealthyphysicalexaminees(controlgroup)inthesamehospitalandduringthesameinterva1.Withregardtoplateletstudygroup:Intermsoftimeofincidence(in48h,49h〜7d,7〜14dandafterl4d)andinfarctsize(larg
6、esizesmalIsizeandlacunarCI)・WeseparatetheCTgroupintodifferentsubgroups,eachsubgroupwerecomparedwithcontrolseparately,andalsomakegroupcomparisonbetweenplateletgroup.ResultsThePLTisthelowestin48hafter'CIonset,butascendgraduallywiththetimedeveloped,andrecoveredtonormallev
7、elatthel4dayspostcurrently(P&11;0.05)・Comparingwithcontrolgroup,MPVandPDWascendmarkedlyin48hafterCTonset(P<0.05)andreachthepeaksa.tthetinieof48h〜7d,thendescendgradually,butevenhigherthaneontrolgroupattherecoveryperiod(P&It;0.05)・Thelargertheinfarctsizeis,thelowerthe
8、PLTis,andthehighertheMPV、PDWare・ConelusionDetectingtheplateletparametersofpatientswithCIandatherosclerosisisvaluablef
