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1、分析手足口病重症的危险因素及临床治疗方案首都医科大学附属北京地坛医院感染二科，北京100015［摘要］目的分析手足口病(HFMD)重症的危险因素及临床治疗方案。方法选取首都医科大学附属北京地坛医院于2010年7月〜2012年7月收治的50例HFMD重症患者作为观察组，50例HFMD轻症患者作为对照组，比较两组患者的临床特点，通过多因素分析筛选出HFMD重症的危险因素。结果对照组和观察组患者在年龄39°C大于3d、血糖〉9mmol/L.意识障碍、精神差、神经反射异常、外周血WBC>12X109/L方
2、何，差异具有统计学意义(P7d、口腔溃疡
3、、肌酸激酶升高方面，二者的差异无统计学意义(P>0.05)；HFMD重症的独立相关因素包括年龄、体温>39°C大于3d、血糖>9mmol/L.精神差、神经反射异常；观察组患者的治愈率为68%,病死率为4%。结论早期检测HFMD重症的危险因素并进行及时的对症治疗可降低手足口病病死率。［关键词］手足口病重症；危险因素；临床治疗方案［中图分类号］R512.5［文献标识码］A［文章编号］1673-7210(2013)11(b)-0063-03Theriskfactorsandclinicaltreatmentprogramsofseverehan
4、d-foot-mouthdiseaseLULianheCIIENZhihaiXUYanliSONGRuiWANGAibinLIXingwangTheSecondDepartmentofInfection,theAffiliatedBeijingDitanHospitalofCapitalMedicalUniversify，Beijing100015,China[Abstract]ObjectiveToanalyzetheriskfactorsandclinicaltreatmentprogramsofseverehand-foot-mou
5、thdisease(HFMD)•Methods50caseswithsevereHFMDfromJuly2010toJuly2012intheAffiliatedBeijingDitanHospitalofCapitalMedicalUniversitywereselectedastheobservationgroup,andother50patientswithmildHFMDwereselectedasthecontrolgroup,thentheclinicalcharacteristicsofthetwogroupswerecom
6、paredandtheriskfactorsofsevereHFMDwerescreenedthroughmulti-factoranalysis・ResultsTheage39°Cinmorethanthreedays,bloodglucose>9mmol/L,disturbanceofconsciousness,thespiritofpoordysreflexia,peripheralbloodWBC>12X109/Linthetwogroupswerefoundhadstatistical1ysignificantdifferene
7、e(P7d,mouthulcers,riseofcreatinekinasebetweenpatientsinthetwogroupswerefoundhadnostatisticallysignificantdifferenee(P>0.05)；theindependentassociatedfactorsofsevereHFMDincludedage,bodytemperature>39°Cformorethan3d,bloodglucose>9mmol/L,poorspiritdysreflexia；thecurerateofpat
8、ientsintheobservationgroupwas68%,andthemortalityratewas4%.ConclusionDetectingtheriskfactorsforsevereHFMDearlyandsymptomatictreatmentintimecanminimizethemortality.[Keywords]Severehand-foot-mouthdisease；Riskfactors；Clinicaltreatmentprograms［基金项目］首都医学发展科研基金项目(编号2009-2090)0［作
9、者简介］卢联合(1967.11-),男，主任医师；研究方向：传染病。手足口病(HFMD)又被称为发疹性水疱性口腔炎，属于一种急性传染病，引发因索为肠道病毒，在我国属于丙类传染病。一般情况下，患
