氟比洛芬酯对鼻内镜术术后镇痛效果的临床观察.doc

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1、氟比洛芬酯对鼻内镜术术并镇痛效果的临床观察［摘要］目的：观察氟比洛芬酯注射液对鼻内镜术术后的镇痛效果及超前镇痛作用。方法：选择择期行鼻内镜术患者60例，采用随机方法分为术前给药组(A纟R)、术后给药组(B组)及对照组(C组),每组各20名。A组于术前15min缓慢静脉注射氟比洛芬酯50mg,B组于术毕缓慢静脉注射氛比洛芬酯50mg,C组不给药，分别观察术后6h和12h的视觉模拟量表(VAS)评分。结果：A组和B组术后6和12hVAS评分均显著低于C组。A组术后6hVAS评分低于B组，但术12h无显著差异。结论：氟比洛芬酯注射液可有效缓解鼻内镜术术后疼痛，且术前给药优于术后给

2、药。［关键词］氛比洛芬酯；鼻内镜术；术后镇痛；超前镇痛［中图分类号］R765.9E文献标识码］B［文章编号11673-7210(2008)05(a)-062-02PostoperativeanalgesiaeffectwithFlurbiprofenAxetilinjectionfornasalondoscopicoperationHUANGJia-vingl,FENGYi-jinl,YUJun-ma2(LDepartmentofOtorhinolaryngologyofHefeiFirstPeople'sHospital,Hefei230061,China；2.Depar

3、tmentofAnesthesiaofHefeiFirstPeople'sHospital,Hefei230061,China)［Abstract］Objective:ToobservepostoperativeanalgesiaandpreemptiveanalgesiaofFlurbiprofenAxetilInjectionfornasalendoscopicoperation.Methods:Atotalof60patientsundergoingnasalendoscopicoperationwererandomizedintothepreoperativeinj

4、ectiongroup(groupA),postoperativeinjectiongroup(groupB)andcontrolgroup(groupC),with20patientsineachgroup.PatientsingroupAandgroupBwereintravenouslyinjecteclwithflurbiprofen50mgpreoperationandpostoperationrespective!y,groupCwasnotadministrated.VASscoreswereobservedat6and12hoursafteroperatio

5、n.Results:VASscoresofgroupAandgroupBafter6and12hoursweresignificantlylowerthangroupC.VASscoresofgroupAafter6hourslowerthangroupB,buttherewasnosignifiedntcliffereneeat12hours.Conclusion:FlurbiprofonAxetilInjectioneffectivelyrelievespostoperativepainofnasalendoscopicoperation,andpreoperative

6、treatmentisbetterthanpostoperativetreatment.［Keywords］FlurbiprofenAxet订Injection；Nasalendoscopicoperation；Postoperativeanalgesia；Preemptiveanalgesia氟比洛芬酯是以脂微球为线物载体的非备体类抗炎线物(NSAIDs),它具有靶向镇痛作用,且作用持久。有研究显示它在骨科、普外科、妇科术后有良好的镇痛作用。鼻内镜术由于创伤小、视野清晰、疗效好而现在被广泛用于治疗慢性鼻窦炎、鼻息肉、鼻腔良性肿瘤等鼻部疾病，但术示病人常出现不同程度的疼痛。

7、木文研究观察了该药在鼻内镜术术麻的镇痛效果。1资料与方法1.1临床资料60例行鼻内镜术患者，男43例，女17例。随机分成：3组，每组各20例，择期在表麻和局麻下行鼻内镜术。术前有严重高血压、心肝肾功能不全、对NSAIDs过敏、有消化性溃疡病史、凝血功能障碍、智力障碍、精神症状以及正在使用依诺沙星、洛美沙星、诺氟沙星的患者不列入观察范围。1.2麻醉方法所有患者均为鼻腔黏膜1%丁卡因表面麻醉和黏膜下1%利多卡因局部浸润麻醉，麻醉前30min肌注鲁米那0.1g,术屮麻醉效果均良好。1.3给药方案采用完全随机设计方法将病例