双乙酰二茂铁缩肼基二硫代甲酸甲酯Schiff碱的合成、晶体结构和生物活性.pdf

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1、第23卷第3期化学研究中国科技核心期刊2012年5月CHEMICALRESEARCHhxyj@henu．edu．cnSynthesis，crystalstructureandbiologicalactivityofdiacetylferrocene—S—methyldithi0carbazateSchiff-baseYANGMin，HEHong—ju，LIYan-ke，LIMing—xue(1．CollegeofChemistryandChemicalEngineering，HenanUniversity，Kaifeng475004，

2、Henan，China；2．HenanSeniorTechnicianSchoolofChemicalIndustry，Kaifeng475002，Henan，China)Abstract：Aferrocene—containingSchiff—baseligand，[(CH3)SSCNHN—C(CH3)(C5H4)]2Fe，wassynthesizedbyusingdiacetylferroceneandS—methy1dithiocarbazateasthestartingmateri—als．Thecomposition，che

3、micalfeatureandcrystalstructureofas—synthesizedproductwereanalyzedbymeansofelementalanalysis，infraredspectrometryandsingle—crystalX-raydiffrac—tion；anditsbiologicalactivitywasevaluated．Resultsindicatethatthetitlecompoundexhibitsmoderateanticanceractivityinthecellgrowthi

4、nhibitionoftheEc9706humanoesophaguscancercel1line．Keywords：ferrocene；S～methyldithiocarbazate；Schiff—base；synthesis；crystalstructure；bio—logicalactivitycLCnumber：O641Documentcode：AArticleID：】008一】0】】(2O】2)03一OO76—06双乙酰二茂铁缩肼基二硫代甲酸甲酯Schiff碱的合成、晶体结构和生物活性杨敏，贺红举，李彦克，李明雪(1．河南大

5、学化学化工学院，河南开封475004；2．河南化学工业技师学院，河南开封475002)摘要：用双乙酰二茂铁和肼基二硫代甲酸甲酯为起始原料，制备了含二茂铁的Schiff碱配体[(CH。)SSCNHN—c(CH。)(cH)]Fe．利用元素分析以及红外光谱和单晶X射线衍射分析了产物的组成、化学特征及晶体结构，并测定了其生物活性．结果表明，标题化合物对Ec9706食管癌细胞株具有适度的生长抑制活性．关键词：二茂铁；肼基二硫代甲酸甲酯；Schiff碱合成；晶体结构；生物活性Inthesearchfornewanticancerdrugs，met

6、alcomplexesandorganometalliccompoundshavearousedconsiderableinterest，duetothetremendousSuccessofclinicallyimportantmetal—basedanticancerdrug，cis—diamminedichloroplatinum(cis一[PtC12(NH3)2])．Recently，studyonseveralferrocenederivativeswithpromisingbiologicalpropertiesshows

7、thattheincorporationofaferrocenefragmentintothemoleculeoforganiccompoundsoftenleadstounexpectedbiologicalactivity[。一．Itisalsoreportedthattheadditionofferrocenemoietytothestructuresofsomedrugsresultsinenhancedactivities[．Furthermore，ferro—ceneisknownasachemicallyandtherm

8、allystableorganometalliccompound[．Thestability，non—toxici—tyandgoodmembrane—permeationabilityoftheferrocenylgr