欢迎来到天天文库
浏览记录
ID:5313784
大小:192.43 KB
页数:2页
时间:2017-12-07
《32例原发性乳腺神经内分泌癌的临床及病理分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、12·论著·November2013,Vo1.11,No.32围衄32~1J原发性乳腺神经内分泌癌的临床及病理分析朱美琴周文斌申维玺夏俊贤徐敏陈敬华(1暨南大学第二临床医学院,深圳市人民医院肿瘤内科,广东深圳518020;2暨南大学第二临床医学院,深圳市人民医院乳腺甲状腺外科,广东深圳518020)【摘要】目的探讨乳腺内分泌癌的临床及病理特征。方法回顾性分析2006年6月至2012年l1月收治的32例女性乳腺神经内分泌癌的·临床特征、病理、治疗及预后。结果患者的平均年龄为53.6岁,雌激素受体(ER)和孕激素受体(PR)阳性表达率较高,人类表皮生长因子受体2(HER2)
2、为(.)~(++)免疫分型15例为LuminalA型,l7例为LuminalB型。12例患者接受乳腺癌根治术,20例患者接受乳腺癌改良根治术。32例均获随访,随访时间4~70个月,中位随访时间为3O个月,均存活,无复发及远处转移。结论乳腺神经内分泌癌好发于老年女性,其免疫分型可能与预后相关,手术治疗和综合治疗的疗效较好,总体预后较好。【关键词l乳腺肿瘤;神经内分泌癌;诊断;治疗中图分类号:R737.9文献标识码:B文章编号:1671-8194(2013)32-0012-02ClinicalandPathologicAnalysisof11CasesofPrimaryBr
3、eastNeuroendocrineCarcinomaZHUMei—qin1ZHOUWen—bin2SHENWei-xilX1AJun-xian1XUMCHENJing-hual....fDepartmentofMedicalOncology,ShenzhenPeople'sHospital,TheSecondClinicalMedicineCollege,JinanUniversity,Shenzhen518024China.2DepartmentofBreastandThyroidSurgery,ShenzhenPeople'sHospital,TheSecondC
4、linicalMedicineCollege,JinanUniversity,Shenzhen5l8o2oChina【Abstraet]ObjectiveToinvestigatetheclinicalandphathologiccharacteristicsofbreastneuroendocrinecarcinoma.Methods32patientswithbreastneuroendocrinecarcinomawereadmittedfromJune2006toNovember2012.Theirclinicalandpathologicaldata,trea
5、tmentandprognesiswereanalyzedretrospectively.ResultsTheaverageageofthe32patientswas53.6years.TheexpressionsofhormonereceptorslikeER(estrogenreceptor)/PR(progesteronereceptor)wereusuallypositiveinNEC,whiletheexpressionofHER2(humanepidermalgrowthfactorreceptor2)wasusuallynegative(一)toposit
6、ive(++).Inmoleculersubtypes,15patientswereLuminalA,17patientswereLuminalB.12patientsreceivedradicalmastectomy,20patientsreceivedmodifiedradicalmastectomy.Allcaseswerefollowed—upaverage30months(range4~70months).Allcaseswerealivewithnorecurrenceanddistantmetastasis.ConclusionsBreastneuroen
7、docrinecarcinomamayaffectolderpatients,andmoleculersubtypesmayberalatedtoprognosis.Surgicalandcomprehensivetherapymayachievesatisfactoryoutcomewithrelativelygoodprognosis,.【Keywords】Breastneoplasms;Neuroendocrinecarcinoma;Diagnosis;Therapy乳腺癌是女性最常见的肿瘤,而神经内分泌癌可发生于人体的多腺神经内分
此文档下载收益归作者所有