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1、三维适形放疗同步替吉奥治疗老年术后复发食管癌的效果观察侯盘长许妍雒建超王伟牛坡河南省人民医院放疗科，河南郑州450003［摘要］目的观察三维适形放疗同步替吉奥化疗治疗老年术后复发食管癌的近期疗效和毒副作用。方法37例老年食管癌术后复发患者，随机分为单放组（19例）和同步组（18例）。放疗应用三维适形放疗（2.0Gy/次，5次/周，总剂量60-66Gy）；同步组：放疗同步口服替吉奥胶囊化疗（40mg/m2,2次/d,口服，连服14d,21d为1个周期）。观察两组疗效及不良反应。结果两组患者均完成治疗，依从性好。同步组有效率为8
2、3.0%,单放组有效率为68.4%,两组比较，差异有统计学意义（P<0.05）o主要毒副作用为放射性食管炎、消化道反应、血液学毒性、放射性皮肤反应，多为1、2级。结论三维适形放疗同步替吉奥化疗治疗食管癌术后复发的疗效确切，毒副作用可耐受，能明显改善患者的生活质量。［关键词］食管肿瘤；放射疗法；三维适形；同期放化疗法；替吉奥［中图分类号］R730.55［文献标识码］A［文章编号］1673-7210（2014）03（b）-0041-04Efficacyobservationofthree-dimensionalconformal
3、radiationcombinedwithS~1treatingforelderlypostoperativeesophagealHOU卩anzhangXUYanLUOJianchaoWANGWeiNTUPoDepartmentofOncologyRadiotherapy,lie'nanProvincialPeople'sHospital,He'nanProvince,Zhengzhou450003,China[Abstract]ObjectiveToobservetherecenteffectandsideeffectof
4、three~dimensionalconformalradiationcombinedwithS~1trentingforelderlypostoperativeesophagealcarcinoma・Methods37patientswithelderlypostoperativeesophagealcarcinomawererandomdividedintoconcurrentchemo-radiotherapy(CCRT)group(n二18)andconventionalradiotherapyalonegroup(
5、CRT)(n二19)•Bothgroupsweretreatedwiththree-dimensionalconformalradiationtherapy(2.0Gy/once,5timesperweekandthetotaldosewas60-66Gy).CCRT：thepatientsweregivenS~1orally40mg/m2twice/dforconsecutive14days,andonecyclelastedfor21days・Theclinicaleffectandaduerseeffectofthet
6、wogroupswerecompared.ResuItsAl1ofthe37patients'treatmentwerefinished・TheeffectiverateofCCRTandCRTwere83.0%and68.4%,thedifferencewasstatisticallysignificant(P<0.05)•Majoradverseeffectswereleukopenia,radiationesophagutis,anemia・ConclusionThree-dimensionalconformalrad
7、iationcombinedwithS~1treatingforelderlypostoperativeesophagealcarcinomahasdefiniteeffect,higheffectiverate,patientsshowwelltolerance,andwithoutserioussideeffect.Itcanapparentlyimprovethe1ifequalityofthepatients.[Keywords]Esophagealcarcinoma；Radiotherapy；3-dimension
8、alconformal；Concurrentchemo-radiotherapy；S~1我国是食管癌的高发国家，随着我国人口老龄化趋势，老年患者在食管癌的发病率构成比呈上升趋势。随着生活水平的提高，就诊的老年食管癌患者一般体质尚可，故外科手术仍是治疗食管癌的主要方法[1],但患者仍常因术后
