适形放疗联合替吉奥治疗老年食管癌的疗效分析.pdf

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1、2013年第17卷第21期实用临床医药杂志JournalofCIinica1MedicineinPractice·105·适形放疗联合替吉奥治疗老年食管癌的疗效分析翟冲亚，叶柯，杨成梁，葛红，邱荣良，刘新菊(郑州大学附属肿瘤医院放疗科，河南郑州，450008)摘要：目的探讨适形放疗联合替吉奥治疗老年食管癌患者的近期疗效及安全性。方法将40例老年食管癌将患者随机分为放疗联合同步替吉奥组(替吉奥组)和放疗联合同步DF方案组(DF组)，每组20例，替吉奥组采用三维适形放疗联合替吉奥进行治疗，DF组采用三维适形放疗联合顺铂+

2、氟尿嘧啶+左亚叶酸钙进行治疗，比较2组患者的治疗完成情况、近期疗效及不良反应发生情况，并按照东部肿瘤协作组(E∞G)标准评价患者。结果替吉奥组完成同步放化疗率显著高于DF组，Ⅲ～Ⅳ级消化道反应及白细胞减少发生率均显著低于DF组，且ECOG评分改善显著优于DF组，差异均有统计学意义。而2组近期疗效比较，差异无统计学意义。结论适形放疗联合替吉奥能有效改善老年食管癌患者的日常体能状态，提高生活质量，且不良反应轻，患者依从性好。关键词：适形放疗；替吉奥；食管癌；顺铂中图分类号：R735．1文献标志码：A文章编号：1672—2

3、353(2013)21—105—03DOI：10．7619／jcmp．201321030Analysisontherapeuticeffectofconformalradi0therapVcombinedwithS一1forelderlypatientswithesophagealcarcinomaZHAIChongya，YEKe，YANGChengliang，GEHong，QIURongliang，LIUXinju(TheAffiliatedTumorHospitalofZhengzhouUniversity，Zh

4、engzhou，Hen口，450008)ABSTRACT：ObjectiveToexploretheclinicaleffectandsafetyofconfoiTnalradiotherapycombinedwithS一1forelderlypatientswithesophagealcarcinoma．MethodsFortyelderlypatientswithesophagealcarcinomawererandomlydividedintoradiotherapyplusconcurrentS一1group

5、(S一1group)andradiotherapyplusconcurrentDFregimengroup(DFgroup)．S一1groupW3Streat—edwithradiotherapyandS一1．whileDFgroupwithradiotherapypluscisplatin+fluorouracil+cal—ciumlevofolinate．Theconditionsoffinishingtreatment．clinicaleffectsandadversereactionswerecompared

6、intwogroups，anddailyperformancestatusofEasternCooperativeOncologyGroup(ECOG)wasevaluated．ResultsTherateofcompletingconcurrentchemoradiotherapyinS一1groupwasmarkedlyhigherthaninDFgroup，incidencesofdigestivereactionsatgradesIll—IVandleucopeniasignificantlylowertha

7、ninDFgroupandECOGscoreobviouslyhigherthaninDFgroup，withsignificantdifferences．Therewasnosignificantdifferencecomparedwithshort—termeffectsoftwogroups．ConclusionConforlTlalradiotherapycombinedwithS一1caneffectivelyamelioratedailyperformancestatusofelderlypatients

8、withesophagealcarcinoma，improvethequalityoflife，hasmildadversereactionsandgoodcompliance．KEYWORDS：conformalradiotherapy；S一1；esophagea1carcinoma；cisplatin随着中国老龄化的加剧，7O岁以上岁老年食