Cys-C和Hcy联合检测对糖尿病肾病诊断的价值.pdf

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1、临京医学工程2014年9月第21卷第9期·1141．·论著·(临床研究)Cys—C和Hcy联合检测对糖尿病肾病诊断的价值陆慧；r-(上海长航医院，上海200122)【摘要】目的探讨Cys-C和Hey联合检测对糖尿病肾病早期诊断的应用价值。方法随机选取我院接收的单纯糖尿病患者8O例、糖尿病肾病患者80例，分为DM和DN两组，另外选取健康体检者8O例为对照组，分别测定三组的Cys—C、Hcy、Scr、Urea、UMA水平。结果DN组Cys-C、Hcy、UMA指标均明显高于DM组和健康体检组(户<0．05)。肾功能I级和Ⅱ级DN患者Scr、Urea与DM组和健康体检组相比，其差异无统计

2、学意义(P>O．05)，Ⅲ级和Ⅳ级DN患者Scr、Urea指标明显高于DM组和健康体检组(P<0．05)。肾功能I级和Ⅱ级患者Cys-C、Hcy、UMA、Cys-C联合Hcy的异常检出率明显高于Scr、Urea的异常检出率。肾功能Ⅲ级和Ⅳ级患者的Cys～C、Hcy、uMA、Cys—C联合Hcy的异常检出率与Scr、Urea的异常检出率相比。其差异无统计学意义(P>0．05)。结论Cys—C、Hey联合检测有助于糖尿病肾病患者的早期诊断，临床应推广应用。【关键词】血清胱抑素C(Cys—C)；同型半胱氨酸(I-Icy)；联合检测；糖尿病肾病(DN)中图分类号：R587．1文献标识码：

3、Adoi：10．39690．issn．1674—4659．2014，09。1141ValueofAssociatedDetectionofSerumCys-CandHeyinDiagnosisofDiabeticNephropathyLUHuihui(ShanghaiChanghangHospital,Shanghai200122,China)【Abstract]ObjectiveToresearchthevalueofassociateddetectionofserurnCys—CandHcyindiagnosisofdiabeticnephropathy．Methods80c

4、asesofsimplediabetesmellitus(DMgroup)，80casesofdiabeticnephropathy(DNgroup)and80healthyphysicalsubjects(controlgroup)wereselectedinthisstudy．Thelevelsofselq．mlCys—C，Hey，Scr，UreaandUMAofthreegroupsweredetected．ResultsThelevelsofCys—C，HeyandU／VIAofDNgroupweresignificantlyhigherthanthoseofDMgrou

5、pandcontrolgroup(P<0．05)．ComparedwithDMgroupandcontrolgroup，theScrandUreaofthepatientswhoserenalfunctionwereIorIIgradeinDNgrouphadnostatisticaldifference<0．05)，whiletheⅢandIVgradepatients’ScrandUreaweresignificantlyhigherthanDMgroupandcontrolgroup<0．05)．Thepatients’abnormalratesofCys-C，Hey，UM

6、A，Cys—CcombinedwithHeyinDNgroupwhoserenalfunctionwereIorI1gradeweresignificantlyhigherthantheabnormalratesofScrandUrea，whilethe11IandIVgradepatients’abnormalratesofCys-C，Hcy，UMA，Cys—CcombinedwithHeyhadnostatisticaldifferencecomparedwiththeabnormalratesofScrandUrea

7、eddetectionofserumCys—CandHeycanhelptotheearlydiagnosisofdiabeticnephropathy，whichisworthyofclinicalapplication．【Keywords】SerumcystatinC(Cys—C)；Homocysteine(Hey)；Associateddetection；Diabeticnephropathy(DN)糖尿病肾病(diabeticnephropathy，DN)是糖尿病尤为常病