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时间:2020-04-23
《通心络对不稳定型心绞痛患者血管内皮功能的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·药物与临床·中国当代医药2014年7月第21卷第21期通心络对不稳定型心绞痛患者血管内皮功能的影响史改英河南省新郑市人民医院心内科,河南新郑451100【摘要】目的观察通心络对不稳定型心绞痛患者血浆内皮素(ET)和一氧化氮(NO)含量的影响。方法将119例不稳定型心绞痛患者随机分为两组,常规治疗59例作为对照组,同时加服通心络胶囊的60例患者为治疗组,分别在住院和治疗后3个月检测ET和NO。采用高分辨率超声法检测肱动脉血流介导的内皮依赖性血管舒张功能(FMD)。结果与治疗前相比,两组治疗前后ET水平均明显下降(P2、心络组较对照组ET水平下降(P3、ology,PeopleSHospitalofXinzhengCityinHenanProvince,Xinzheng451100,China【Abstract】ObjectiveToobservetheeffectofTongxinluoonfunctionofvascularendothelin(ET)andnitricoxide(NO)inpatientswithUnstableanginapectoris.Methods119patientswithunstableanginapectoriswererandomlydividedintotwogroup4、s.The59casesweretreatedbyconventionaltherapyaloneasthecontrolgroup,the60casesweretreatedbyconventionaltherapyplusTongxinluoasthetreatmentgroup.Thechangeofbloodlevelsofendothelinandnitricoxidewereobservedfrombeforetreatmenttoafterthreemonthsoftreatment,theflow-mediateddilatation(FMD)i5、nbrachialarterywasdetectedatthesametimeusingultrasonography.ResultsAftertreatment,bloodlevelsofETobvi—ouslydecreased(尸<0.o1),thelevelofNOandFMDobviouslyincreased(P<0.01)inbothgroups.Comparedwiththecontrolgroupaftertreatment,thebloodlevelsofETintreatedgroupwerelower(P<0.05),thelevelof6、NOandFMDwerehigher(P<0.01).ConclusionTongxinluobyanticoagulation,fallfat,reducetheadhesionmoleculesandreduceET,andimprovethelevelofNOwaytoimproveendothelialfunction,protecttheintegrityofthecapillaries一【Keywords】Unstableanginapectoris;Functionofendothelium;Tongxinluo梗死后心绞痛属于不稳定型心绞痛,冠状7、动脉造等,诊断符合中华医学会心血管分会制订的标准[3】;并影或CTA显示多数存在多支血管不同程度狭窄或多经冠状动脉造影或CTA证实的1l9例患者,年龄发粥样斑块形成,冠状动脉不足以维持心肌代谢的需43~79岁。平均(66.7±11.2)岁,对照组59例,男40例,要从而发生心绞痛。血管内皮功能异常在其发病过程女,19例。通心络组60例,男46例,女14例。两组患中起至关重要的作用。通心络应用中医络病的理论探者的一般资料差异无统计学意义(P>0.05),具有可讨冠心病心绞痛的中医病理机制,具有益气活血、通比性。络止痛的功效『l】。本研究通过不稳定型心绞痛患者血1.8、2治疗方法浆内皮素(ET
2、心络组较对照组ET水平下降(P3、ology,PeopleSHospitalofXinzhengCityinHenanProvince,Xinzheng451100,China【Abstract】ObjectiveToobservetheeffectofTongxinluoonfunctionofvascularendothelin(ET)andnitricoxide(NO)inpatientswithUnstableanginapectoris.Methods119patientswithunstableanginapectoriswererandomlydividedintotwogroup4、s.The59casesweretreatedbyconventionaltherapyaloneasthecontrolgroup,the60casesweretreatedbyconventionaltherapyplusTongxinluoasthetreatmentgroup.Thechangeofbloodlevelsofendothelinandnitricoxidewereobservedfrombeforetreatmenttoafterthreemonthsoftreatment,theflow-mediateddilatation(FMD)i5、nbrachialarterywasdetectedatthesametimeusingultrasonography.ResultsAftertreatment,bloodlevelsofETobvi—ouslydecreased(尸<0.o1),thelevelofNOandFMDobviouslyincreased(P<0.01)inbothgroups.Comparedwiththecontrolgroupaftertreatment,thebloodlevelsofETintreatedgroupwerelower(P<0.05),thelevelof6、NOandFMDwerehigher(P<0.01).ConclusionTongxinluobyanticoagulation,fallfat,reducetheadhesionmoleculesandreduceET,andimprovethelevelofNOwaytoimproveendothelialfunction,protecttheintegrityofthecapillaries一【Keywords】Unstableanginapectoris;Functionofendothelium;Tongxinluo梗死后心绞痛属于不稳定型心绞痛,冠状7、动脉造等,诊断符合中华医学会心血管分会制订的标准[3】;并影或CTA显示多数存在多支血管不同程度狭窄或多经冠状动脉造影或CTA证实的1l9例患者,年龄发粥样斑块形成,冠状动脉不足以维持心肌代谢的需43~79岁。平均(66.7±11.2)岁,对照组59例,男40例,要从而发生心绞痛。血管内皮功能异常在其发病过程女,19例。通心络组60例,男46例,女14例。两组患中起至关重要的作用。通心络应用中医络病的理论探者的一般资料差异无统计学意义(P>0.05),具有可讨冠心病心绞痛的中医病理机制,具有益气活血、通比性。络止痛的功效『l】。本研究通过不稳定型心绞痛患者血1.8、2治疗方法浆内皮素(ET
3、ology,PeopleSHospitalofXinzhengCityinHenanProvince,Xinzheng451100,China【Abstract】ObjectiveToobservetheeffectofTongxinluoonfunctionofvascularendothelin(ET)andnitricoxide(NO)inpatientswithUnstableanginapectoris.Methods119patientswithunstableanginapectoriswererandomlydividedintotwogroup
4、s.The59casesweretreatedbyconventionaltherapyaloneasthecontrolgroup,the60casesweretreatedbyconventionaltherapyplusTongxinluoasthetreatmentgroup.Thechangeofbloodlevelsofendothelinandnitricoxidewereobservedfrombeforetreatmenttoafterthreemonthsoftreatment,theflow-mediateddilatation(FMD)i
5、nbrachialarterywasdetectedatthesametimeusingultrasonography.ResultsAftertreatment,bloodlevelsofETobvi—ouslydecreased(尸<0.o1),thelevelofNOandFMDobviouslyincreased(P<0.01)inbothgroups.Comparedwiththecontrolgroupaftertreatment,thebloodlevelsofETintreatedgroupwerelower(P<0.05),thelevelof
6、NOandFMDwerehigher(P<0.01).ConclusionTongxinluobyanticoagulation,fallfat,reducetheadhesionmoleculesandreduceET,andimprovethelevelofNOwaytoimproveendothelialfunction,protecttheintegrityofthecapillaries一【Keywords】Unstableanginapectoris;Functionofendothelium;Tongxinluo梗死后心绞痛属于不稳定型心绞痛,冠状
7、动脉造等,诊断符合中华医学会心血管分会制订的标准[3】;并影或CTA显示多数存在多支血管不同程度狭窄或多经冠状动脉造影或CTA证实的1l9例患者,年龄发粥样斑块形成,冠状动脉不足以维持心肌代谢的需43~79岁。平均(66.7±11.2)岁,对照组59例,男40例,要从而发生心绞痛。血管内皮功能异常在其发病过程女,19例。通心络组60例,男46例,女14例。两组患中起至关重要的作用。通心络应用中医络病的理论探者的一般资料差异无统计学意义(P>0.05),具有可讨冠心病心绞痛的中医病理机制,具有益气活血、通比性。络止痛的功效『l】。本研究通过不稳定型心绞痛患者血1.
8、2治疗方法浆内皮素(ET
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