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《不同剂量依托咪酯脂肪乳持续输注对犬血脂及血糖的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第23卷第20期中国现代医学杂志V01.23No.202013年7月ChinaJournalofModernMedicineJu1.2013文章编号:10O5—8982(2013)20—0035—04·论著·不同剂量依托咪酯脂肪乳持续输注对犬血脂及血糖的影响秦榜勇,胡红专,曹保锋,朱昭琼(遵义医学院附属医院麻醉科,贵州遵义563003)摘要:目的对比观察不同剂量依托咪酯持续输注麻醉维持对犬血脂及血糖的影响。方法健康成年雄性犬24只。随机分为4组(n=6),对照组(C组):2.5%戊巴比妥钠基础麻
2、醉气管插管后输注等量生理盐水;实验组:E,、E、E3组,在气管插管后分别持续输注依托咪酯乳剂10、20、30g/(kg·rain)维持麻醉3h。持续监测并记录各组生命体征及血糖浓度的变化,分别于气管插管前(Tn)、气管插管后1h(T)、2h(T)、3h(T,)取股静脉血栓测血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A,(APOA)、载脂蛋白B(APOB)的变化。结果4组各指标均在正常范围内。对照组与实验组各时间点心率(HR
3、)、平均动脉压(MAP)、TG、TC、HDL—C、LDL—C、APOA及血糖浓度均在正常范围,与对照组比较差异无统计学意义(P>O.05);APOB浓度在E3组1r3时点降低(P4、eindogsQINBang-yong,HUHong-zhuan,CAOBao—feng,ZHUZhao—qiong(DepartmentofAnesthesiology,theAffliatedHospitalofZunyiMedicalCollege,Zunyi,Guizhou563003,P.R.China)Abstract:【Objective】TocomparetheeffectsofdifferentdosesEtomidatecontinuousinfusioningenerala5、nesthesiaindogsonbloodlipidandbloodglucose.【Methods】Twenty—fourhealthyadultmaledogswererandomlydividedinto4groups(n=6):controlgroup(groupC)withonlysodiumpentobarbitalanesthesia,andthreeexperimentalgroups:E1,E2,E3threegroupsreceivedinfusionofEtomidate6、attherateof10g/(kg‘min),20Ixg/(ks·rain),30g/(kg’min)3hrespectively.Thedogswerealsoanesthesitizedwith2.5%sodiumpentobarbitone(1mL/kg)intraperitonealandcatheteredinfemoralarteryandfemoralvein.Ineverygroupvi—talsignweremonitoredandHR,MAPandbloodglucosew7、ererecorded.Bloodsamplesweretakenfromfemoralveinfordeterminationofserumconcentrationsoftriglyeride(TG),totalcholesterolC),highdensitylipoproteincholesterol(HDL—C)’lowdensitylipoproteincholesterol(LDL—C),apolipoproteinA1(APOA1),apolipoproteinB(APOB)be8、foreintubationfr0),at1h,2h,3hafterintubation(Tl_3).【Results】AUthepa-rametersinthe4groupswereinthenormalranges.ComparedwithgroupC,theconcentrationofTG,TC,HDL—C,LDL—C,APOA1andbloodglucose,HRandMAPwiththetimesanddosesinGroupE1—3werenosignificantdifferen
4、eindogsQINBang-yong,HUHong-zhuan,CAOBao—feng,ZHUZhao—qiong(DepartmentofAnesthesiology,theAffliatedHospitalofZunyiMedicalCollege,Zunyi,Guizhou563003,P.R.China)Abstract:【Objective】TocomparetheeffectsofdifferentdosesEtomidatecontinuousinfusioningenerala
5、nesthesiaindogsonbloodlipidandbloodglucose.【Methods】Twenty—fourhealthyadultmaledogswererandomlydividedinto4groups(n=6):controlgroup(groupC)withonlysodiumpentobarbitalanesthesia,andthreeexperimentalgroups:E1,E2,E3threegroupsreceivedinfusionofEtomidate
6、attherateof10g/(kg‘min),20Ixg/(ks·rain),30g/(kg’min)3hrespectively.Thedogswerealsoanesthesitizedwith2.5%sodiumpentobarbitone(1mL/kg)intraperitonealandcatheteredinfemoralarteryandfemoralvein.Ineverygroupvi—talsignweremonitoredandHR,MAPandbloodglucosew
7、ererecorded.Bloodsamplesweretakenfromfemoralveinfordeterminationofserumconcentrationsoftriglyeride(TG),totalcholesterolC),highdensitylipoproteincholesterol(HDL—C)’lowdensitylipoproteincholesterol(LDL—C),apolipoproteinA1(APOA1),apolipoproteinB(APOB)be
8、foreintubationfr0),at1h,2h,3hafterintubation(Tl_3).【Results】AUthepa-rametersinthe4groupswereinthenormalranges.ComparedwithgroupC,theconcentrationofTG,TC,HDL—C,LDL—C,APOA1andbloodglucose,HRandMAPwiththetimesanddosesinGroupE1—3werenosignificantdifferen
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