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《Ki-67在人肝癌组织中的表达特点-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、医学2013年l2月第21卷第12期MODERNONCOLOGY.Dec.2013.VOL.21.NO.12·2759·enterology,2008,135(5):1469—1492.『12]JonathanStrosberg,RomanCasciano,LeeStem,eta1.UnitedllOJTakehimOkabayashi,YasuoShima,TatsuakiSumiyoshi.eta1.Di.States——basedpracticepatternsandresourceutilizationinad.agn
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3、:谈静)Ki一67在人肝癌组织中的表达特点罗曼,曹颖,文安智ExpressionofKi一67antigeninhumanhepatocellularcarcinomaLuoMin‘,CaoYing,WenAnzhiDepartmentofOncology;DepartmentofPathology,GuizhouProvincialPeopleHospital,GuizhouGuiyang550002,China.【Abstract】Objective:Tostudytherelationshipbetweenclinica
4、lpathologicalfeaturesandtheexpressionofKi一67inhepatocellularcarcinoma.Methods:ImmunohistochemistrywasusedtodetecttheKi一67expression1evelincancertissuefromlivercancerresectionspecimens.andtoanalyzethecorrelationbetweenKi一67expressionandva—riousclinicopathologiealfeat
5、ures.Results:In48casesofhepatoeeilularcarcinoma,Ki一67wasexpressedin40ca-ses,thepositiveratewas83.3%,noexpression48casesoftissueadjacenttocancer(P<0.01).TheexpressionlevelofKi一67inHCCtissueswasnegativelycorrelatedwithage(r=一0.331,P=0.011),positivelycorrelatedwiththel
6、iverhistopathologicaldifferentiationgrade(r=0.361,P=0.012),andcirhosis(r=一0.341,P=0.018),gender(r=0.375,P=0.009)wasalsocorelatedwithKi一67.Butfortumorsize,nodules,HBsAg,AFPandcapsuleinvasion,nocorelationwasfound.Conclusion:Inhumanhepatocellularcarcinomatissue.theexpr
7、essionlevelofKi一67ishigherthaninnoncanceroustissue,andhascorrelationwithpathologicalgrade,age,genderandlivercirhosis.【Keywords】hepatoeellularcarcinoma;Ki一67antigen;immunohistochemistry;correlationanalysisModernOncology2013,21(12):2759—2761【摘要】目的:探讨原发性肝癌中Ki一67的表达和临床病
8、理特征的关系。方法:运用免疫组化法检测肝癌切除的癌组织标本Kj一67表达水平,并分析Ki一67表达水平与多种临床病理特征之间的相关性。结果:l(i一67在48例肝癌组织中,4O例有程度不同的表达,阳性率为83.3%,在48例相应癌旁组织无表达(P<0.o1)。肝癌组织中I
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