妊娠期肝内胆汁淤积症胆汁酸、肝酶指标对妊娠结局的影响-论文.pdf

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1、·临床研究·十一医药斜2014年8月第4卷第15期妊娠期肝内胆汁淤积症胆汁酸、肝酶指标对妊娠结局的影响黄满辉张翠广东省东莞市清溪医院妇产科，广东东莞523660[摘要】目的探讨妊娠期肝内胆汁淤积症患者的胆汁酸、肝酶指标对患者妊娠结局的影响，为临床诊治妊娠期肝内胆汁淤积症患者给予参考。方法选择2012年1月一2013年10月我院收治的170例妊娠期肝内胆汁淤积症患者作为临床研究对象，对所有患者均给予胆汁酸、肝酶指标的检测，根据检测结果将患者分为轻度、中度和重度，并以同期我院收治的150例正常健康孕妇作为对照组，观察比较四组孕妇的妊娠结局。结果产后

2、出血方面：重度妊娠期肝内胆汁淤积症患者的发生率最高，差异有统计学意义(P<0．05)；重度妊娠期肝内胆汁淤积症患者剖宫产比例更高，新生儿窒息率更高，低体重儿比例高，新生儿Apgar评分低，与其他组别对比差异有统计学意义。结论对妊娠期肝内胆汁淤积症检测胆汁酸、肝酶指标，有助于判断患者的疾病严重程度，进而评估产妇和新生儿结局。【关键词】妊娠期肝内胆汁淤积症；胆汁酸；肝酶指标；妊娠结局【中图分类号】R714．7【文献标识码】B【文章编号】2095—0616(2014)15—158-03Influenceofbileacidsandliverenzym

3、eindicatorsofgestationalpatientswithintrahepaticcholestasisonpregnancyoutcomesHUANGManhuiCujDepartmentofGynecologyandObstetrics，DongguanQingxiHospital，Dongguan523660，China[Abstract]ObjectiveToanalyzetheinfluenceofthebileacidsandliverenzymeindicatorsofgestationalpatientswithi

4、ntrahepaticcholestasisonthepregnancyoutcomesandprovidereferencefortheclinicaldiagnosisandtreatmentofgestationalpatientswithintrahepaticcholestasis．Methods170gestationalpatientswithintrahepaticcholestasistreatedinourhospitalfromJanuary2012toOctober2013wereselectedastheclinica

5、lstudysubjectsandallthepatientsweregivenbileacidsandliverenzymeindicatorsdetection．Thepatientsweredividedintothemild，moderateandseveregroupsaccordingtothedetectionresuhsand150normalhealthypregnantwomenadmittedtoourhospitalinthesameperiodwereselectedasthecontrolgroup．Thepregn

6、ancyoutcomesofthefourgroupsofpregnantwomenwereobserved．ResultsRegardingtOpostpartumbleeding，thegestationalpatientswithsevereintrahepaticcholestasisbadthehighestincidence．withstatisticallysignificantdifference(P

7、higherproportionofcesareansection，higherneonatalasphyxiarate，higherproportionoflowbirthweightinfantsandlowerneonatalApgarscore，withstatisticallysignificantdifferencestotheothergroups．ConclusionThedetectionofbileacidsandliverenzymeindicatorsofthegestationalpatientswithintrahe

8、paticcholestasisisconducivetodeterminingtheseverityofillnessandthusevaluati