甲状腺功能减退症及亚临床甲状腺功能减退症患者的血脂变化研究.pdf

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1、医堂盍年3月第36卷第2期JournalofNavvMedicine．V01．36．N0．2．Mar．2015·107·．论著．甲状腺功能减退症及亚临床甲状腺功能减退症患者的血脂变化研究韩晓光[摘要]目的观察甲状腺功能减退症(甲减)及亚临床甲状腺功能减退症(亚甲减)患者血脂的状况，并分析亚甲减患者促甲状腺素(TSH)值与血脂间的关系。方法收集2011年1月至2014年6月在我院内分泌科门诊及病房就诊的甲减患者(甲减组)133例、亚临床甲减患者(亚甲减组)146例，并收集同期在我科门诊或病房检查甲状腺功能正常者86例作为对照组，比较各组血脂的变化；将亚甲减组按TSH分层分为亚甲减．

2、1组、亚甲减-2组，并与对照组比较。结果甲减组总胆固醇(CHO)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL—c)高于对照组，高密度脂蛋白胆固醇(HDL—C)低于对照组，差异均有统计学意义(P<0．05)；亚甲减组CHO、LDL—C均明显高于对照组，差异有统计学意义(P<0．05)；分层后，亚甲减．1组CHO与对照组比较有升高趋势，但差异无统计学意义(P>0．05)，TSH>10U／L亚甲减组CHO、TG、LDL—C均明显高于对照组，差异有统计学意义(P<0．05)。结论甲减及亚甲减患者血脂明显升高，且亚甲减-2组患者血脂升高与TSH值升高有关，临床应予重视。[关键词]甲状腺动

3、脉功能减退症；亚临床甲状腺动脉功能减退症；血脂[中图分类号]R581[文献标识码]A[DOI]10．3969／j．issn．1009—0754．2015．02．004ResearchonlipidchangesinpatientswithhypothyroidismandsubclinicalhypothyroidismHanXiaoguang(PeopleSHospital，LinyiEconomicandTechnologicalDevelopmentZone，Linyi276023，China)[Abstract]0bjectiveToobservelipidlevelsi

4、npatientswithhypothyroidismandsubclinicalhypothyroidismandalsotoana—lyzetherelationshipbetweenthyroid—stimulatinghormone(TSH)andlipidlevelinpatientswithsubclinicalhypothyroidism．MethodsOnehundredandthirty—threepatientswithhypothyroidismand146patientswithsubclinicalhypothyroidism，whosoughtmedi

5、calcarefromJanuary2010toJune2014intheoutpatientandinpatientdepartmentsofthehospitalwererespectivelyassignedasthehypothyroid—ismgroupandthesubclinicalhypothyroidismgroup．Another86examinees，whosoughtmedicaladviceduringthesameperiod，butwithnormalthyroidfunction，wereusedasthecontrolgroup．Changesi

6、nlipidlevelswerecomparedbetweenthegroups．Thesubclini—calhypothyroidismgroupwasfurtherdividedintothesubclinicalhypothyroidismgroup1andgroup2inaccordancewithTSHlevels，andthentheywerecomparedwiththenormalcontrolgroup．ResultsForthehypothyroidismgroup，thelevelsoftotalcholesterol，tri—glyceride(TG)a

7、ndlow—densitylipoproteincholesterol(LDL—C)werehigherthanthoseofthecontrolgroup，whilethelevelofhigh—densitylipoproteincholesterol(HDL-C)waslowerthanthatofthecontrolgroup，andstatisticalsignificancecouldbeseen，whencon—parisonsweremadebetweenthem