胃癌相关血液标志物的研究进展.pdf

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1、·1298·聂娜，等胃癌相关血液标志物的研究进展[23]BmughR，FrankumJR，Costa—CabralS，eta1．Searchingforsyn—humanmodels[J]．JClinInvest，2010，120：3940—3952．thetielethalityincancer[J]．CurrOpinGenetDev，2011，21：34[27]OjiY，MiyoshiS，MaedaH，eta1．OverexpressionoftheWilms—41．tumorgenewT1indenovolungcancers【J]．IntJC

2、ancer，2002，[24]BarbieDA，TamayoP，BoehmJS，eta1．SystematicRNAinterfer-100：297—303．eneerevealsthatoneogenicKRAS—drivenCsnce~requireTBKI[28jKumarMS，HancockDC，Molina—ArcasM，eta1．TheGATA2[J]．Nature，2009，462：108—112．transcriptionalnetworkisrequisiteforRASoneagene—drivennon[25]OuYH，Tone

3、sM，RamR。eta1．TBKIdirectlyengagesAkt／PKB—smallcelllungcancer[J]．Cell，2012，149：642—655．survivalsignalingtosupportoncogenictransformation[J]．Mol[29]JannePA，ShawAT，PereiraJR，eta1．SelumetinibplusdocetaxelCell，2011，41：458—470．forKRAS—mutantadvancednon—small—celllungcancer：A[26]Vicent

4、S，ChenR，SaylesLC，eta1．Wilmstumor1(wT1)regu—randomised，multicentre，placebo—controlled，phase2study[J]．latesKRAS—drivenoneogenesisandsenescenceinmouseandLancetOncol，2013，14：38—47．(编校：谈静)胃癌相关血液标志物的研究进展聂娜，骞佩，冯英明TheprogressaboutthebloodmarkersforgastriccarcinomaNieNa，QianPei，FengYing

5、minglDepartmentofOncology，TangduHospital。FourthMilitaryMedicalUniversity，ShaanxiXi"an710038，ChinaGraduateSchoolofFM—MU，ShaanxiXitm710032，China．【Abstract】Gastriccancerisoneofthemostcommonmalignanttumor，itsearlydiagnosisandtreatmentcansignifi．candyimprovethepatientssurvivalrate．C

6、onventionaltumormarkersintheearlydiagnosisofgastriccancerplaysaveryimportantrole，butbecauseofitslowsensitivityandspecificity，leadingtoacertaindegreeofmisseddiagnosisandmisdiagnosis．Inrecentyears，avarietyofanewgenerationofgastriccancerbiomarkershavebeenfoundinlabo-ratorydiagnosi

7、s，thebloodasabiologicaltestsample，conveniently，notraumatic，andtheadvantagesofcontinuoustes—tinginvitro，eanlookingforasimple，quick，withoutdamage，hasgreatclinicalapplicationvalue．Therecentprogres—sesinthebloodmarkersofgastriccancerhavebeenreviewedinthispaper．【Keywords】cancer；gast

8、riccancer；blodmarkersModemOncology2015，23(09)：1298—130