肾嗜酸细胞腺瘤临床病理分析并文献复习.pdf

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1、·94·解放军医药杂志2015年2月第27卷第2期Med＆PharmJChinPLA，Vo1．27，No．2，Feb．2015肾嗜酸细胞腺瘤临床病理分析并文献复习吴永芳，王晶晶，许春伟，刘翠，张博，满秋红，王怀涛，李晓兵，韩双[摘要]目的探讨肾嗜酸细胞腺瘤的临床病理学特点及诊断要点。方法对我院收治的肾嗜酸细胞腺瘤3例的临床资料、病理形态学及免疫组化结果进行分析，并结合文献对其诊断及鉴别诊断进行探讨。结果本组中。肾占位2例，肾上腺占位1例。镜下可见肿瘤细胞排列呈实性巢索状、乳头状或呈腺泡结构，胞质

2、丰富，嗜酸，间质少，伴透明样变性；瘤细胞呈圆形或多角形，细胞核圆形规则，染色质分布均匀，核仁位于中央，核分裂象少见。免疫组化显示CK、EMA表达均阳性，Vimentin、Hale胶体铁表达均阴性。病理诊断肾嗜酸细胞腺瘤。结论肾嗜酸细胞腺瘤较少见，提高对该病的认识，对避免误诊至关重要。[关键词]肾肿瘤；腺瘤，嗜酸粒细胞；病理学，临床；免疫组化[中国图书资料分类号]R737．11；R730．261[文献标志码]B[文章编号]2095—140X(2015)02—0094—04[DOI]10．3969／

3、j．issn．2095—140X．2015．02．026CUnic0path0logicAnalysisandliteratureReviewofRenalOncocytomawUYong—fang，WANGJing-jing，XUChun—wei，LIUCui，ZHANGBo，MANQiu—hong，WANGHuai—tao，LIXiao—bing，HANShuang(DepartmentofPathology，AfiliatedHospitalofAcademyofMilitaryMedic

4、alSciences，Beijing100071，China)[Abstract]ObjectiveToexploretheclinieopath0logiccharacteristicsanddiagnosticcriteriaofrenaloncocyto—ma．MethodsTheclinicaldata，pathomorphologyandimmunohistochemicalstainingresultsof3patientswithrenalon—cocytomawereanalyz

5、ed，anditsdiagnosisanddiferentialdiagnosiswerestudiedincombinationofwiththeliterature．ResultsTwopatientswerefoundtohavekidneylesion．andonepatientwasfnundtohaveadrenalmass．Microscopicexaminationshowedthatthetumorceilswerearrangedintheformofsolidnest，pa

6、pillaryoracinarstructures，andwithabundanteosinophiliccytoplasmandlesshyalinedegenerationininterstitialtissue；thetumorcellswereroundorpolygo—nal，andthecellnucleuswasroundandregular，chromatinwaswelldistributed，thenucleoluswaslocatedcentrally，andtherewe

7、reraremitoticfigures．ImmunohistochemicalstainingshowedthattheexpressionsofCKandEMAwerepositive，andtheexpressionsofVimentinandHalecolloidalironstainingwerenegative．Pathologicdiagnosiswasrenaloncocyto-ma．ConclusionRenaloncocytomaisrare，anditisessential

8、toavoidmisdiagnosisbyraisingawarenessofthedisease．[Keywords]Kidneyneoplasms；Adenoma，oxyphilic；Pathology，clinical；Immunohistochemistry肾嗜酸细胞腺瘤作为一种良性上皮性肿瘤，临痛缓解；1周前再次出现上述症状，就诊当地医院行床少见，为避免误诊，提高对本病的认识，我们CT检查示：右肾上极局限性膨隆，可见一类圆形稍对军事医学科学院附属医院病理科诊断为肾嗜酸细低密度影，直径2