髓系细胞触发受体-1和CRP在胸腔积液中的表达及意义-论文.pdf

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1、浙江临床医学2014年9~J第l6卷第9期·1373··临床研究·髓系细胞触发受体一1和CRP在胸腔积液中的表达及意义李小波张蓉映任应鹏沈华浩【摘要】目的探讨髓系细胞触发受体一1(TREM．1)、CRP在不同性质的胸腔积液中表达水平和意义。方法收集胸腔积液患者，检测胸腔积液和血清中TREM．1、CRP水平，检i贝0胸腔积液细胞膜TREM一1mRNA的表达。统计不同类型胸腔积液TREM．1、CRP表达水平的差异。结果(1)TREM．1检测显示：与结核性、肿瘤性和漏出性三组胸腔积液比较，肺炎旁胸腔积液sTREM．1表达显著增高。肺炎旁胸腔积液组血清sTREM一1与肿瘤性、漏出性胸腔积液组比较，

2、表达均显著增高，但与结核性胸腔积液组比较无明显差异。(2)CRP检测显示：结核性和肺炎旁胸腔积液CRP水平均显著高于肿瘤性和漏出性胸腔积液。但结核性胸腔积液和肺炎旁胸腔积液CRP水平无显著差异。结核性胸腔积液组和肺炎旁胸腔积液组血清CRP水平均显著高于肿瘤性胸腔积液组和漏出性胸腔积液组，但结核性胸腔积液组和肺炎旁胸腔积液组血清CRP水平无显著差异。结论胸腔积液sTREM．1水平可以作为判断肺炎旁胸腔积液的重要参考指标。【关键词】髓系细胞触发受体一1C反应蛋白胸腔积液【Abstraet】objectiveToinvestigatetheexpressionandsignificanceofT

3、REM一1、CRPindiferenttypesofpleuraleffusion．MethodsThesamplesofpleuraleffusionwerecollectedfromtheoutr'atientandhospitalizedpatientsinourhospita1．ThelevelofsTREM一1、CRPinpleuraleffusionandserumweredetected,theexpressionofpleuralefusioncellmembraneTREM-1mRNAwasdetected．ThedifferentlevelsofsTREM—IandCR

4、Pbetweenvarioustypesofpleuralefusionwerestatisticallyanalyzed．Results(1)TREM一1detection：theexpressionofsTREM一1inparapneumonicpleuraleffusionwassignificantlyhigher,comparedwithtuberculosis，malignantandtransudativepleuraleffusion．Comparedwithgroupofmalignantandtransudatepleuraleffusion，theserumsTREM

5、一1levelingroupofinparapneumonicpleuralefusionwasincreasedsignificantly．Buttherewasnosignificantdiferencecomparedwithgroupoftuberculouspleuralefusion．(2)CRPdetection：Intuberculousandparapneurnonicefusion，theCRPlevelsweresignificantlyhigherthanthatinmalignantandtransudativepleuraleffusion．Therewasno

6、significantdiferenceofCRPlevelbetweentuberculousandparapneumonicefusions．TheselMmCRPlevelsingroupoftuberculousandparapneumonicpleuralefusionweresignificantlyhigherthanthatinmalignantandtransudativepleuralefusiongroups．ButtherewasnosignificantdiferenceofserunlCRPlevelbetweentuberculouspleuralefusio

7、ngroupandparapneumonicpleuralefusiongroup．ConclusionThelevelofsTREM一1inpleuralefusioncanbeusedasanimportantreferenceindexofjudgingparapneumonicefusion．【Keywords】Triggeringreceptorexpressedonmyeloidcells一1Creactiv